Objective: To investigate the effect and safety of breviscapine combined with energy mixture in the treatment of sudden deafness.Methods: 214 patients with sudden deafness hospitalized from January 2013 to December 2016 were chosen and randomly divided into the observation group and the control group, 107 patients in each group. The observation group was treated with breviscapine combined with mecobalamine energy mixture, while the control group was treated only with energy mixture, with the clinical effect and safety observed.Results: The total effective rate was 95.33 % in the observation group, which was significantly higher than that in the control group (74.77%)(χ²=9.335,P=0.010. The total effective rate of tinnitus improvement was 94.52%, which was significantly higher than that of the control group (86.84%)(χ²=3.546,P=0.042). The total effective rate if dizziness improvement in the observation group was 95.59%, which was significantly higher than that in the control group (84.85%)(χ²=3.587,P=0.041).Conclusion: Breviscapine combined with mecobalamine energy mixture in the treatment of sudden deafness can effectively restore the hearing of patients, improve the clinical symptoms of vertigo and tinnitus, worthy of promotion.