Objective: To explore effects of skull defect and titanium mesh repair on skull growth and intelligence development in juvenile rats. Methods: 3-week-old SD rats were randomly divided into the sham operation control group (SOC group), skull defect group (SD group) and titanium mesh repair group (TMR group). Differences among the three groups were excluded before surgery. Rats were reared to sexual maturity in the same environment for open field test and Morris water maze test after operation, and then sacrificed. The body weight, skull line, skull thickness, defect diameter and brain volume were measured. Results: Body weight and skull diameter line showed no statistical difference among the three groups before operation (P＞0.05), and they were comparable. There were no differences on body weight, skull line and brain volume at the time of sexual maturity among the three groups (P＞0.05). Only the average thickness of rats in the SOC group was slightly thicker than the other two groups (P＜0.05). There was no difference between the SD group and TMR group in terms of the inner diameter of skull defect (P＞0.05), and the defects were elongated comparing with that before operation. By comparing the SD group and the other two groups, differences in terms of total distance, average speed and quiescent time were found in the open field experiment (P＜0.05). Morris water maze test showed that there were differences between SD group and other groups in terms of escape latency on day 5, first crossing platform time and proportion of target quadrant time (P＜0.05). Conclusions: The unrepaired skull defect had no obvious effect on the normal growth of skull in juvenile rats, but might affect their intellectual development. Titanium mesh repair does not limit the skull growth of juvenile rats, and could avoid the possible native influence to the intellectual development in rats with skull defect without repair. Reliable evidence to Repair Skull Defect Early in Children was provided in this study and the Gliding Theory enriched.
SHEN Jie
,
SHAO Guo
,
ZHANG Chunyang
,
ZHAO Zhijun
. Effects of skull defect and titanium mesh repair on skull growth and intelligence development in juvenile rats[J]. Journal of Baotou Medical College, 2023
, 39(1)
: 28
-34
.
DOI: 10.16833/j.cnki.jbmc.2023.01.007
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