Objective: To investigate the changes and clinical significance of platelet (PLT) parameters, fibrinogen (FIB), fibrinogen degradation products (FDP), and D-D two dimers in acute ischemic stroke patients after thrombolytic therapy, and to assess the correlation between smoking, diabetes, hypertension, and hyperlipidemia with acute ischemic stroke. Methods: The blood samples of 309 patients with acute ischemic stroke (the observation group) within 24 hours of onset and 303 healthy people (the control group) were collected. The platelet parameters (PLT and MPV) and the levels of fibrinogen (FIB), fibrinolytic products (FDP) and D-D dimer in the acute attack stage and after thrombolytic treatment were measured, the data of the two groups and the observation group before and after treatment were compared, and the correlation between the risk factors (diabetes, hypertension, hyperlipidemia, smoking) and the incidence of acute ischemic stroke in the observation group were analyzed. Results: Comparing with the control group, the level of PLT decreased and MPV increased in the observation group, and the levels of D-Dimer, FIB and FDP of the observation group were higher. The difference between the two groups was statistically significant (P＜0.05). The levels PLT, MPV, D-Dimer, FIB and FDP at acute attack stage and after thrombolytic therapy in the observation group were also significantly different. Smoking and other risk factors, such as diabetes, hypertension, hyperlipidemia, are correlated with the incidence of acute ischemic stroke. Conclusion: The combined detection of PLT, MPV and anticoagulant markers D-D dimer, FIB and FDP could provide an important reference for the evaluation of treatment effect of prehospital acute ischemic stroke.
ZHU Jiajia
,
WANG Li
,
LI Zongji
. Clinical significance of platelet parameters and anticoagulation related biomarkers in acute ischemic stroke[J]. Journal of Baotou Medical College, 2023
, 39(1)
: 8
-12
.
DOI: 10.16833/j.cnki.jbmc.2023.01.003
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