Clinical significance of platelet parameters and anticoagulation related biomarkers in acute ischemic stroke

  • ZHU Jiajia ,
  • WANG Li ,
  • LI Zongji
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  • 1. Research Center of Medical Science and Technology, Ningxia Medical University, Yinchuan 750004, China;
    2. Department of Laboratory Medicine, School of Clinical Medicine, Ningxia Medical University

Received date: 2022-09-08

  Online published: 2023-03-07

Abstract

Objective: To investigate the changes and clinical significance of platelet (PLT) parameters, fibrinogen (FIB), fibrinogen degradation products (FDP), and D-D two dimers in acute ischemic stroke patients after thrombolytic therapy, and to assess the correlation between smoking, diabetes, hypertension, and hyperlipidemia with acute ischemic stroke. Methods: The blood samples of 309 patients with acute ischemic stroke (the observation group) within 24 hours of onset and 303 healthy people (the control group) were collected. The platelet parameters (PLT and MPV) and the levels of fibrinogen (FIB), fibrinolytic products (FDP) and D-D dimer in the acute attack stage and after thrombolytic treatment were measured, the data of the two groups and the observation group before and after treatment were compared, and the correlation between the risk factors (diabetes, hypertension, hyperlipidemia, smoking) and the incidence of acute ischemic stroke in the observation group were analyzed. Results: Comparing with the control group, the level of PLT decreased and MPV increased in the observation group, and the levels of D-Dimer, FIB and FDP of the observation group were higher. The difference between the two groups was statistically significant (P<0.05). The levels PLT, MPV, D-Dimer, FIB and FDP at acute attack stage and after thrombolytic therapy in the observation group were also significantly different. Smoking and other risk factors, such as diabetes, hypertension, hyperlipidemia, are correlated with the incidence of acute ischemic stroke. Conclusion: The combined detection of PLT, MPV and anticoagulant markers D-D dimer, FIB and FDP could provide an important reference for the evaluation of treatment effect of prehospital acute ischemic stroke.

Cite this article

ZHU Jiajia , WANG Li , LI Zongji . Clinical significance of platelet parameters and anticoagulation related biomarkers in acute ischemic stroke[J]. Journal of Baotou Medical College, 2023 , 39(1) : 8 -12 . DOI: 10.16833/j.cnki.jbmc.2023.01.003

References

[1] Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American heart association/American stroke association[J]. Stroke, 2018, 49(3): e46-e110.
[2] Wang WZ, Jiang B, Sun HX, et al. Prevalence incidence and mortality of stroke in China[J]. Circulation, 2017, 135(8): 759-771.
[3] Furie KL, Jayaman MV. 2018 Guidelines for the early management of patients with acute ischemic stroke[J]. Stroke, 2018, 49(3): 509-510.
[4] Smith EE, Saver JL, Cox M, et al. Increase in endovascular therapy in get with the guidelines-stroke after the publication of pivotal trials[J]. Circulation, 2017, 136(24): 2303-2310.
[5] 唐伯儒, 刘洋, 郭阳. 平均血小板体积与心脑血管疾病的研究进展[J]. 中国老年学杂志, 2018, 38(8): 2030-2032.
[6] Hussein HM, Saleem MA, Qureshi AI. Statewide trends in utilization and outcomes of endovascular treatment of acute ischemic stroke: analysis of Minnesota hospital association data[J]. J Stroke Cerebrovasc Dis, 2018, 27(3): 677-681.
[7] Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct[J]. N Engl J Med, 2018, 378(1): 11-21.
[8] Xie DW, Xiang WW, Weng YY, et al. Platelet volume indices for the prognosis of acute ischemic. Stroke patients with intravenous thrombolysis[J]. Int J Neurosci, 2019, 129(4): 344-349.
[9] Yao YQ, Cao XJ, Zou RC, et al. Study on the baseline factors and platelet indices that predict outcome of acute ischemic stroke patients after thrombolytic therapy[J].Cerebrovasc Dis,2022,51(3):357-364.
[10] Ot S, Zafar L, Beg M, et al. Association of mean platelet volume with risk factors and functional outcome in acute ischemic stroke[J]. J Neurosci Rural Pract, 2021, 12(4): 764-769.
[11] Wang CY, Wang L, Deng LH, et al. Association between mean platelet volume and hemorrhagic transformation in acute ischemic stroke patients[J]. Curr Neurovasc Res, 2020, 17(1): 3-10.
[12] Nezu T, Kitano T, Kubo S, et al. Impact of D-dimer levels for short-term or long-term outcomes in cryptogenic stroke patients[J]. J Neurol, 2018, 265(3): 628-636.
[13] 胡佳, 周伟, 周志明, 等. 炎症指标对缺血性脑卒中卒中后抑郁的预测价值[J]. 南方医科大学学报, 2019, 39(6): 665-671.
[14] Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging[J]. N Engl J Med, 2018, 378(8): 708-718.
[15] Fargen KM, West JL, Mocco J. Lifting the veil on stroke outcomes: revisiting stroke centers' transparency through public reporting of metrics[J]. J Neurointerv Surg, 2018, 10(9): 839-842.
[16] Macovei L, Magopet R, Tanasa A, et al. Coronary artery bypass graft surgery versus percutaneous coronary intervention in unprotected left main coronary artery disease: a systematic review[J]. Rev Cardiovasc Med, 2020, 21(1): 65-73.
[17] Alam L, Agrawal K, Kankanala V, et al. Primary cardiac undifferentiated high-grade intimal pleomorphic sarcoma: a case series report[J]. Cardiol Res, 2020, 11(2): 129-133.
[18] Agasthi P, Lee JZ, Pujari SH, et al. Safety and efficacy of direct oral anticoagulants compared to Vitamin K antagonists postpercutaneous coronary interventions in patients with atrial fibrillation: a systematic review and meta-analysis[J]. J Arrhythm, 2020, 36(2): 271-279.
[19] Hsia CH, Jayakumar T, Sheu JR, et al. Synthetic ruthenium complex TQ-6 potently recovers cerebral ischemic stroke: attenuation of microglia and platelet activation[J]. J Clin Med, 2020, 9(4): 996.
[20] Nishanth KR, Math RS, Shankar M, et al. Thrombolysis with reteplase in acute pulmonary embolism[J]. Indian Heart J, 2019, 71(6): 464-467.
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