Objective: Protein structure determines its function. In order to understand protein function, it is necessary to understand protein structure. With the development of gene sequencing, a large number of primary structures of proteins have been detected, but it is still difficult to predict the advanced structures directly from the sequence of proteins, especially the prediction of tertiary structures. However, the structural information obtained from the super secondary structure can be used for the prediction of the tertiary structure,which is of great significance to predict the three-dimensional structure and function of proteins.Methods: Based on the primary structure, Fisher's criterion was used to distinguish two strand-loop-Strand supersecondary structure modules, considering the amino acid sequence information and hydrophilicity of amino acids.Results: When the Loop length was 2-8, the final average result was Q= 71.8 %, QL= 68.2 %, QH= 73.4 %, MCC =0.39.If the loop lengths differ little, the prediction results are better. For example, if the loop lengths are 2, 3 and 4, the 7 cross test results are Q= 75.2 %, QL = 69.4 %, QH = 77.7 % and MCC =0.45.Conclusion: Using amino acid information as characteristic index, Fisher's criterion can distinguish two strand-loop-Strand supersecondary structure modules well.
LI Caiyan
,
DIND Haimai
,
WU Lan
,
HE Haiyan
,
WEN Haokun
. Classifying of two kinds of Strand-Loop-Strand protein motifs[J]. Journal of Baotou Medical College, 2023
, 39(1)
: 1
-3
.
DOI: 10.16833/j.cnki.jbmc.2023.01.001
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