Objective: To explore the clinical effect of the superficial branch of radial nerve nutrient vessel flap in repairing hand skin defect. Methods: From May 2016 to January 2020, 114 patients with hand skin defects weretreated in the Sixth People's Hospital of Longgang District were selected and divided into radial nerve group (n=57) and control group (n=57) according to random number table method. The radial nerve group was treated with superficial radial nerve nutrient vessel flap repair, and the control group was treated with adjacent flap. The prognosis of the two groups was recorded and followed up. Results: All patients were successfully completed the operation. The duration of hospitalization, the time of complete wound coverage, the number of dressing changes and the time of wound healing in the radial nerve group were less than those in the control group (P＜0.05). The excellent and good rate of flap blood supply texture in the radial nerve group 3 months after operation was 98.2 %, which was higher than 86.0 % in the control group (P＜0.05). The incidence of venous crisis, scar contracture, wound necrosis, wound infection and other complications in the radial nerve group at 3 months after operation was 3.5 %, which was lower than 17.5 % in the control group (P＜0.05). After one year of follow-up, the hand sensory recovery function in the radial nerve group was better than that in the control group (P＜0.05). The satisfaction rate of the radial nerve group was 100.0 %, which was higher than 89.5 % of the control group (P＜0.05). Conclusion: Compares with adjacent flaps, the application of superficial radial nerve nutrient vascular flaps can accelerate the recovery of hand sensory function in patients with hand skin defect, improve the blood supply, texture excellent rate and satisfaction of the flap, and reduce the incidence of complications.