Objective: To investigate the clinical value of CT in the diagnosis of localized pancreatitis.Methods: 160 cases of patients with localized pancreatitis who were diagnosed and treated from January 2010 to December 2016 were enrolled in observation group, and 160 patients with common pancreatitis were admitted to control group. The patients in both groups were diagnosed with conventional CT and CT enhanced scan.Results: There was no significant difference in the changes of renal fascia morphology and the incidence of pseudocyst in the two groups (P＞0.05). The incidence rates of single CT sign, pancreatic enlargement and unclear pancreas in observation group were significantly higher than those in control group (P＜0.05). The BF and BV values in observation group were significantly lower than those in control group, while the MTT and PS values were significantly higher than those in control group (P＜0.05).Conclusion: The clinical CT diagnosis of localized pancreatitis can effectively improve the accuracy and effectiveness of identification and diagnosis, with good imaging features and quantitative parameters. It has a good application value.