Objective: To observe the clinical characteristics of mycoplasma pneumoniae pneumonia in children, and to explore the role of community acquired respiratory distress syndrome toxin (CARDS TX) and serum IL-1β expression in the pathogenesis of mycoplasma pneumoniae pneumonia. Methods: A total of 120 children with community-acquired pneumonia hospitalized in our hospital from 2019 to 2020 were selected as the research objects and divided into severe mycoplasma pneumonia group (SMPP, 30 cases), non-severe mycoplasma pneumonia group (NSMPP, 50 cases) and non-mycoplasma pneumonia group (NMPP, 40 cases). All subjects underwent bronchial lavage fluid CARDS TX levels and peripheral venous blood IL-1β, blood biochemistry, inflammatory markers, coagulation function test. Results: (1) The levels of CARDS TX and IL-1β in SMPP group were higher than those in NSMPP group, and those in NSMPP group were higher than those in NMPP group, the differences were statistically significant (P＜0.05). (2) The level of lactate dehydrogenase (LDH) in SMPP group was higher than that in NSMPP and NMPP groups, and the differences were statistically significant (P＜0.05). (3) The levels of C-reactive protein (CRP) and ferritin in SMPP group were higher than those in NMPP group, and the level of procalcitonin (PCT) in NMPP group was higher than those in SMPP and NSMPP groups, the differences were statistically significant (P＜0.05). (4) Prothrombin time (PT), PT activity (PT%) and partial prothrombin time (APTT) in SMPP group were shorter than those in NSMPP group and NMPP group; the fibrinogen (FIB) in SMPP group was higher than that in NSMPP group and higher than that in NMPP group; the D-dimer (D-Di) in SMPP group was higher than that in NSMPP and NMPP groups, and the differences were statistically significant (P＜0.05). Conclusion: (1) CARDS TX can lead to respiratory tract injury, and increase the production of inflammatory cytokines IL-1β. Clinically, mycoplasma pneumonia can be diagnosed by CARDS TX detection, which provides a theoretical basis for further targeted treatment. (2) Severe inflammatory reaction after mycoplasma infection provides strong evidence for anti-inflammatory treatment. (3) High coagulation dysfunction in mycoplasma infection is the cause of thrombosis in mycoplasma infection, which is the influencing factor of refractory and severe mycoplasma infection.
QU Yanjie
,
GAO Shuqing
,
Sun Hongxia
,
WANG Dongmei
,
DONG Chunfeng
,
WANG Peixia
. Clinical features and pathogenesis of mycoplasma pneumoniae pneumonia in children[J]. Journal of Baotou Medical College, 2022
, 38(10)
: 64
-69
.
DOI: 10.16833/j.cnki.jbmc.2022.10.013
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