Objective: To investigate the correlation of serum matrix metallopro-teinase-3 (MMP-3), tissue inhibitor of metalloproteinases-1 (TIMP1), tissue inhibitor of metalloproteinases-2 (TIMP2), serum bone bridging protein 1 (SPP1) and plasminogen (PLG) with disease activity in patients with remissive seronegative symmetric synovitis with depression edema (RS3PE). Methods: Twenty-one patients (RS3PE group) with RS3PE syndrome diagnosed and treated in the Department of Rheumatology and Immunology, Second Affiliated Hospital of Baotou Medical College from May 2020 to July 2021 were collected, and 30 healthy people were selected as the control group (CON group). The expression levels of MMP-3, TIMP1, TIMP2, SPP1 and PLG genes and proteins in serum were detected by real-time quantitative PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) in both groups. The rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), X-ray manifestations and magnetic resonance imaging (MRI) manifestations of the two groups were summarized. Results: Compared with the CON group, the expression levels of ESR, CRP, MMP-3, TIMP1, TIMP2, and SPP1 were significantly higher in the RS3PE group (P＜0.01), and there was no significant change in PLG expression levels (P＞0.05); the expression levels of MMP-3, TIMP1, TIMP2, and SPP1 were significantly and positively correlated with ESR and CRP. Conclusion: The expression levels of MMP-3, TIMP1, TIMP2 and SPP1 in serum of patients with RS3PE are significantly increased, and their expression levels are significantly positively correlated with ESR and CRP levels, suggesting that MMP-3, TIMP1, TIMP2 and SPP1 may be involved in the occurrence and development of RS3PE, and are closely related to the degree of disease activity.
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