Effect of Cyclooxygenase-2 Inhibitor on Gastric Mucosa in Rats with Adjuvant Arthritis

  • HE Qing ,
  • DING Ruifeng ,
  • LI Min ,
  • CHEN Nan ,
  • WU Kun ,
  • ZHANG Aimin
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  • The First Affiliated Hospital of Baotou Medical College,Baotou 014010, China

Received date: 2022-09-15

  Online published: 2023-01-06

Abstract

Objective: To investigate whether selective COX-2 inhibitors aggravate gastric mucosal injury and its mechanism in adjuvant induced arthritis rats. Methods: 32 male SD rats were randomly divided into blank control group, arthritis control group, normal administration group and arthritis administration group. They were given celecoxib, a selective COX-2 inhibitor, by gavage for 4 weeks. Then take the gastric tissue of rats for HE staining injury score and gross injury score. Results: The pathological score and gross score of gastric mucosal injury in arthritis control group and arthritis administration group were higher than those in blank control group; There was no significant difference in the pathological score and gross score of gastric mucosal injury between the normal administration group and the blank control group; There was no significant difference in the pathological score and gross score of gastric mucosal injury between the arthritis administration group and the arthritis control group. Conclusion: At the therapeutic dose, celecoxib, a selective COX-2 inhibitor, did not cause gastric mucosal damage in normal rats or aggravate gastric mucosal damage in adjuvant arthritis rats. There was gastric mucosal injury in adjuvant arthritis rats. Gastric mucosal injury in adjuvant arthritis rats may be related to the systemic chronic inflammation caused by arthritis.

Cite this article

HE Qing , DING Ruifeng , LI Min , CHEN Nan , WU Kun , ZHANG Aimin . Effect of Cyclooxygenase-2 Inhibitor on Gastric Mucosa in Rats with Adjuvant Arthritis[J]. Journal of Baotou Medical College, 2022 , 38(12) : 32 -35 . DOI: 10.16833/j.cnki.jbmc.2022.12.007

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