Objective: To explore the distribution and main genotypes of HPV-infected people in Baotou area, so as to put forward corresponding countermeasures for prevention and control. Methods: Descriptive research method was used to select women who were tested for HPV from July to December 2020 as the research object.The general situation and disease status of the subjects were investigated.At the same time, cervical epithelial exfoliated cells were collected, and HPV typing was detected by PCR-reverse dot hybridization. Results: Among the 1 138 patients investigated, 254 were infected, the infection rate was 22.32 %, of which the low-risk infection rate was 13.56 %, and the high-risk infection rate was 86.68 %; there were 76 cases with multiple infections, accounting for 29.92 %.The top five infections were HPV16:19.69 %; HPV52:17.32 %; HPV53, HPV58 and HPV42:11.02 %.Among the age groups, the highest infection rate was 32.69 % in 60-70 years old group.The number of gynecological outpatients was 226 (88.98 %), only 12 patients (4.72 %) took the initiative to detect HPV infection. Conclusion: HPV infections are mainly single type, of which high-risk infections account for a high proportion, and the awareness of an active detection is weak.Health education should be strengthened to improve the awareness of active detections, so as to facilitate the early detection, early diagnosis and early treatment of HPV infections.