Objective: To investigate the relationship between Chemerin, lipid metabolism and gestational diabetes mellitus in pregnant women with different body sizes before pregnancy. Methods: A total of 60 pregnant women with gestational diabetes mellitus (GDM) diagnosed at 24-28 weeks of gestation according to the WHO diagnostic criteria in 2013 were selected from the obstetric outpatient department of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology from October 2018 to October 2019.They were divided into the standard group (BMI 18.5-23.9 kg/m2), the overweight group ( BMI 24-28 kg/m2) and the obesity group (BMI≥28 kg/m2) according to the level of pre-pregnancy body mass index (BMI), with 20 cases in each group.In addition, 20 pregnant women with normal blood glucose and BMI of 18.5-23.9 kg/m2 were selected as the control group.All the selected subjects were delivered at 37-40 weeks.The age, height and pre-pregnancy weight of pregnant women were recorded in detail after admission; at the same time, fasting blood glucose, fasting insulin, glycosylated hemoglobin, blood lipids (total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) and high-sensitivity CRP (hs-CRP) were measured before delivery in each group, and insulin resistance index (HOMA-IR) was calculated.Chemerin value in peripheral blood was determined by enzyme-linked immunosorbent assay. Results: The Chemerin, fasting blood glucose, fasting insulin, glycosylated hemoglobin, HOMA-IR, triglyceride, low-density lipoprotein cholesterol and hs-CRP in three GDM groups were higher than those in the normal control group.The Chemerin, fasting blood glucose, fasting insulin, glycosylated hemoglobin, HOMA-IR and hs-CRP in the GDM overweight and GDM obese groups were higher than those in the GDM standard group; the triglyceride and low-density lipoprotein cholesterol in the GDM obese group were higher than those in the GDM standard group. Conclusion: GDM pregnant women with overweight and obesity before pregnancy have higher risk of risk of abnormal glucose and lipid metabolism, increased inflammation and metabolic syndrome.
CHEN Peng
,
HAN Bei
,
GE Hua
,
LUO Jin
,
DANG Ting
,
WANG Xiaoying
,
JU Jinzhe
. Study on glucose and lipid metabolism of Chemerin in pregnant women with gestational diabetes mellitus[J]. Journal of Baotou Medical College, 2022
, 38(9)
: 52
-55
.
DOI: 10.16833/j.cnki.jbmc.2022.09.012
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