Objective: To explore the expression of serum amyloid A (SAA) in the peripheral blood of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and its application in the classification of CRSwNP. Methods: A total of 40 healthy volunteers and 87 patients with CRSwNP were included in this study.The latter were further divided into the eosinophilic CRSwNP (ECRSwNP) group (n=47) and non-eosinophilic CRSwNP (NECRSwNP) group (n=40), the concentration of SAA in the peripheral blood of each group was detected, and we conducted correlation analysis between SAA and the clinical indicators.The diagnostic value of SAA for ECRSwNP was evaluated with the binary logistic regression and the receiver operator characteristic curve (ROC). Results: The concentration of SAA in peripheral blood of the CRSwNP group was (148.70±7.01) mg/L, which was significantly higher than that of control group (0.46 ±0.05) mg/L, P＜0.0001).Compared with the NECRSwNP group (120.20±11.39) mg/L), the ECRSwNP group showed a significant increase in peripheral blood SAA concentration (168.70±9.47) mg/L, P=0.001).The correlation analysis suggested the SAA concentration is positively associated with the proportion (r=0.333,P=0.002)of the tissue eosinophils and the count of peripheral blood eosinophil (r=0.316,P=0.003).The ROC curve suggested that the peripheral blood SAA was an acceptable biomarker in diagnosing ECRSwNP (AUC=0.712,P=0.001). Conclusion: The concentration of SAA increased significantly in the peripheral blood of the CRSwNP patients and was associated with the eosinophilic inflammation.The peripheral blood SAA may be an efficient and noninvasive biomarker to diagnose ECRSwNP.
JIANG Yuanwei
,
HU Weiqun
,
CAI Zhifu
,
DAI Huting
,
LIN Chaofan
,
PAN Jinxia
. Serum amyloid A level in patients with chronic rhinosinusitis with nasal polyps and application in tissue typing[J]. Journal of Baotou Medical College, 2022
, 38(9)
: 31
-35
.
DOI: 10.16833/j.cnki.jbmc.2022.09.007
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