Objective: To observe the efficacy and adverse reaction of neoadjuvant chemotherapy with high-dose methotrexate (MTX), epirubicin (EPI) and cisplatin (PDD) for stage Ⅱb osteosarcoma. Methods: The efficacy and adverse reactions of high dose methotrexate ( 10-12 g/m2), epirubicin (80 mg/m2) and cisplatin (75 mg/m2) combined chemotherapy in 25 patients with pathological diagnosis, initial treatment and stage Ⅱb limb osteosarcoma were analyzed. Results: The success rate of limb salvage was 76 %, the 5-year PFS rate reached 72 %: the 5-year recurrence and metastasis rate was 28 %, and the 5-year survival rate was 72 %.The most common adverse reactions were hematological toxic neutropenia, anemia, thrombocytopenia, and liver function damage.Non-hematological toxicity was alopecia, nausea and vomiting, diarrhea, and oral mucositis, mostly mild to moderate.The incidences of grade Ⅲ-Ⅳ nausea, vomiting, neutropenia, alopecia and liver dysfunction were 32 %, 36 %, 68 % and 4 %, respectively. Conclusion: High-dose methotrexate, epirubicin and cisplatin combined with neoadjuvant therapy for stage Ⅱb osteosarcoma has high limb salvage success rate, high 5-year survival rate, low recurrence and metastasis rate, exact curative effect, mild adverse reactions and good tolerance, which is worthy of clinical promotion and use.
ZHENG Jialei
,
MO Huanhuan
,
WU Xiao
,
FANG XIANG
,
HU Ting
. Efficacy analysis of high-dose methotrexate, epirubicin combined with cisplatin in neoadjuvant chemotherapy for osteosarcoma[J]. Journal of Baotou Medical College, 2022
, 38(9)
: 10
-14
.
DOI: 10.16833/j.cnki.jbmc.2022.09.003
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