Objective: To investigate the effect of pretreatment with dexmedetomidine and dezocine on rocuronium injection pain.Methods: 120 cases of patients under general anaesthetic for elective surgery were randomly divided into 4 groups (n=30): control group (group C), dexmedetomidine group (group Y), dezocine group (group D) and dexmedetomidine and dezocine unions group (group L). They received normal saline 5 ml, dexmedetomidine 0.5μg/kg, dezocine 0.1 mg/kg, and dexmedetomidine 0.5 μg/kg combined with dezocine 0.1mg/kg respectively. The incidences of injection pain and fentanyl-induced cough were observed and the changes of blood pressure (BP) and heart rates (HR) were monitored and recorded.Results: Compared with group C, the incidences of injection pain and fentanyl-induction cough in group Y, group D, and group L significantly decreased (P<0.05); the incidences of injection pain and fentanyl-induction cough in group L were lower than those in group Y and group D (P<0.05). After anesthesia induction, HR and the amplitude of mean arterial pressure (MAP) in group Y and L were significantly slower than those in group C and D (P<0.05).Conclusion: Pre-injection of dexmedetomidine and dezocine before anesthesia induction can significantly reduce rocuronium injection pain, promote the stability of anesthesia induction circulation, and reduce the incidence of fentanyl-induction cough.
KONG Deqiang
,
XU Min
,
QI Dunyi
. Effects of pretreatment with dexmedetomidine and dezocine on rocuronium injection pain[J]. Journal of Baotou Medical College, 2017
, 33(9)
: 28
-30
.
DOI: 10.16833/j.cnki.jbmc.2017.09.011
[1] 古玲玲,陈峰.罗库溴铵注射痛的预防研究进展[J].山东医药,2014,54(11):93-95.
[2] Eyigor C,Ceylan A,Demir F,et a1.Superficial venous thrombophlebitis caused by roeuronium[J].Anesth,2010,24(4):646-648.
[3] 徐志杰,靳红绪,孙学飞,等.地佐辛预处理减轻罗库溴铵注射痛的效果观察[J].成都医学院学报,2014,9(1):65-67.
[4] 曾思,温开兰,蔡兵,等.预先静脉注射右美托咪定和利多卡因对罗库溴铵注射痛的影响[J].国际麻醉学与复苏杂志,2014,35(5):401-404.
[5] Monso J,Reis F.Dexmedetomidine:current role in anesthesia andintensive care[J].Rev Bras Anestesiol,2012,62(1):118-133.
[6] 王志,唐显玲.α2-肾上腺素受体激动剂右美托咪定在围手术期的应用进展[J].医学综述,2010,16(20):3173-3175.
[7] 徐志杰,靳红绪,孙学飞,等.地佐辛预处理减轻罗库溴胺注射痛的效果观察[J].成都医学院学报2014,9(1):64-67.
[8] Sun ZT,Yang CY,Zhang J,et al.Effect of intravenous Dezocine on fentanyl-induced cough during general anesthesia induction:a double-blinded,prospective,randomized,controlled trial[J].J Anesth,2011,25(6):860-863.