Objective: To investigate the clinical efficacy of abdominal douche during laparoscopic appendectomy in the treatment of pediatric acute suppurative appendicitis complicated with peritonitis. Methods: The clinical data of 61 children undergoing laparoscopic appendectomy were retrospectively analyzed. They were divided into study group (22 children) and control group (39 children) according to whether abdominal douche was performed during operation. The hospitalization time, postoperative complications, perioperative inflammation and immune related indexes were compared between the two groups. Results: The hospitalization time of the study group was shorter than that of the control group[9(7, 9)d vs 10(9, 12)d, P=0.004]; there was no significant difference in the incidence of postoperative complications between the two groups. At 12 h after operation, the level of serum C-reactive protein (CRP) in the study group was lower than that in the control group (P=0.009). At 72 h after operation, the white blood cell count (WBC), neutrophil percentage (NEUT) and CRP levels in the study group were better than those in the control group (all P＜0.05), but there was no significant difference in procalcitonin (PCT) levels between the two groups (all P＞0.05). In terms of immune indexes, there was no significant difference in preoperative indexes between the two groups (all P＞0.05). At 72 h after operation, the levels of IgA (P＜0.001) and IgM (P＜0.001) in the study group were higher than those in the control group, and there was no significant difference in other immune indexes (all P＞0.05). Conclusion: Abdominal douche during laparoscopic appendectomy can effectively reduce the early inflammatory response, improve the immune function and shorten the hospitalization time.
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