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丹皮酚介导BNIP3对线粒体自噬的影响及其治疗帕金森病的研究进展*

  • 温俊威 ,
  • 马婧 ,
  • 谢宇薪 ,
  • 张珂凡 ,
  • 薛继娇 ,
  • 席富强
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  • 1.包头医学院,内蒙古包头 014040;
    2.包头医学院第一附属医院神经内一科
席富强,薛继娇

收稿日期: 2025-05-27

  网络出版日期: 2026-04-28

基金资助

*内蒙古自治区自然科学基金项目(2024LHMS08057);内蒙古医学科学院公立医院科研联合基金科技项目(2023GLLH0198);2023包头市卫生健康科技计划项目(2023wsjkkj54)

Research progress on the effect of paeonol-mediated BNIP3 on mitophagy and its treatment of Parkinson's disease

  • WEN Junwei ,
  • MA Jing ,
  • XIE Yuxin ,
  • ZHANG Kefan ,
  • XUE Jijiao ,
  • XI Fuqiang
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  • 1. Baotou Medical College, Baotou 014040, China;
    2. The First Department of Neurology, the First Affiliated Hospital of Baotou Medical College

Received date: 2025-05-27

  Online published: 2026-04-28

摘要

帕金森病(PD)是一种常见的神经退行性疾病,其主要病理特征是中脑黑质多巴胺能神经元的进行性丧失和路易小体的形成;尽管目前治疗PD的药物可以在一定程度上缓解症状,但仍无法根治该疾病,且很难改善PD引起的抑郁、睡眠障碍、认知障碍等非运动症状,长期使用甚至会引发显著的副作用。丹皮酚是一种酚类化合物,其分子结构简单,脂溶性较强,易于通过血脑屏障进入中枢神经系统,进而发挥其抗氧化、抗炎、抑制细胞凋亡、促进线粒体自噬等作用;丹皮酚可在一定浓度范围内通过抑制线粒体氧化应激的发生,减轻神经细胞线粒体功能损伤,维持细胞内线粒体功能稳定,发挥其神经保护作用。

本文引用格式

温俊威 , 马婧 , 谢宇薪 , 张珂凡 , 薛继娇 , 席富强 . 丹皮酚介导BNIP3对线粒体自噬的影响及其治疗帕金森病的研究进展*[J]. 包头医学院学报, 2026 , 42(3) : 90 -98 . DOI: 10.16833/j.cnki.jbmc.2026.03.018

Abstract

Parkinson's disease (PD) is a common neurodegenerative disease. The main pathological features of PD are the progressive loss of dopaminergic neurons in the substantia nigra and the formation of Lewy bodies. Although the current drugs for PD can alleviate symptoms to a certain extent, they still cannot cure the disease, and it is difficult to improve non-motor symptoms such as depression, sleep disorders, and cognitive impairment caused by PD. Moreover, long-term drug administration may induce significant adverse effects. Paeonol, a phenolic compound characterized by its simple molecular structure and high lipophilicity, readily crosses the blood-brain barrier to exert neuroprotective effects in the central nervous system. These effects are mediated through multiple mechanisms including antioxidant activity, anti-inflammatory properties, inhibition of apoptotic pathways, and enhancement of mitophagy. Within a specific concentration range, paeonol has been shown to mitigate mitochondrial oxidative stress, attenuate neuronal mitochondrial dysfunction, maintain mitochondrial homeostasis, and thereby demonstrate neuroprotective efficacy.

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