目的: 探讨多种血清肿瘤标志物在2型糖尿病(T2DM)患者中的表达及与糖脂代谢的关系。方法: 将2018年6月-2020年5月期间滨州市中心医院收治的T2DM患者128例根据有无合并症分为单纯糖尿病组(n=72)、并发症组(n=56),并选取同期本院体检者作为对照组(n=50)。对比各研究组血清肿瘤标志物及糖脂代谢指标水平的差异,观察T2DM患者多种肿瘤标志物与糖脂代谢指标的相关性。结果: 与对照组比较,单纯糖尿病组和并发症组血清糖类抗原19-9(CA19-9)、糖类抗原15-3(CA15-3)、癌胚抗原(CEA)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FIN)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的含量均升高(P＜0.05),且并发症组又高于单纯糖尿病组(P＜0.05);通过相关性分析,T2DM患者血清中CA19-9、CA15-3、CEA的含量与糖脂代谢指标FBG、HbA1c、FIN、HOMA-IR、TC、HDL-C、LDL-C的水平呈正相关(P＜0.05)。结论: T2DM患者血清CA19-9、CA15-3、CEA的含量增高,且其增高程度与糖脂代谢异常程度呈正相关,可作为T2DM病情判断的辅助指标。
Objective: To investigate the expression of multiple serum tumor markers in patients with type 2 diabetes mellitus (T2DM) and its relationship with glucose and lipid metabolism. Methods: A total of 128 patients with T2DM admitted to Binzhou Central Hospital from June 2018 to May 2020 were divided into simple diabetes group (n=72) and complication group (n=56) according to the presence or absence of complications, and the subjects who underwent physical examination in our hospital during the same period were selected as the control group (n=50). The differences of serum tumor markers and glucose and lipid metabolism indexes in each group were compared, and the correlation between various tumor markers and glucose and lipid metabolism indexes in T2DM patients was observed. Results: Compared with the control group, the levels of serum carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), fasting insulin (FIN), insulin resistance index (HOMA-IR), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the simple diabetes group and the complication group were increased (P＜0.05), and those in the complication group were higher than those in the simple diabetes group (P＜0.05). Correlation analysis showed that the levels of serum CA19-9, CA15-3 and CEA in T2DM patients were positively correlated with the levels of glucose and lipid metabolism indexes FBG, HbA1c, FIN, HOMA-IR, TC, HDL-C and LDL-C (P＜0.05). Conclusion: The levels of serum CA19-9, CA15-3 and CEA in patients with T2DM are increased, and the degree of increase is positively correlated with the degree of abnormal glucose and lipid metabolism, which can be used as an auxiliary index to judge the condition of T2DM.
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