目的:探究孕妇血清中轻稀土元素含量与小于胎龄儿的相关性。方法:基于包头市孕妇前瞻队列,构建巢式病例对照研究,病例组选取44例小于胎龄儿,对照组选取132例适于胎龄儿;通过病历系统收集孕妇相关资料,采用电感耦合等离子体质谱法,检测孕妇血清中轻稀土元素浓度。结果:小于胎龄儿组镧元素与钕元素浓度中位数显著高于对照组,其余轻稀土元素以及轻稀土元素总量两组未见差异。调整混杂因素后,镧元素(OR=2.91;95%CI:1.19-7.10)、钕元素(OR=2.14;95%CI: 1.02-4.51)与小于胎龄儿的关联性仍具有统计学意义。结论:孕妇血清中镧元素和钕元素的高浓度与小于胎龄儿的发生密切相关,会增加小于胎龄儿的发生风险。
Objective: To investigate the correlation between the concentrations of light rare earth elements in the serum of pregnant women and the incidence of small for gestational age infants. Methods: A nested case-control study was conducted based on a prospective cohort of pregnant women in Baotou City. The case group included 44 cases of small for gestational age infants, while the control group included 132 appropriate-for-gestational-age infants. Relevant maternal data were collected through medical records systems. The concentrations of light rare earth elements in maternal serum were measured using inductively coupled plasma mass spectrometry. Results: The median concentrations of lanthanum and neodymium in the small for gestational age infants group were significantly higher than those in the control group, and there was no difference in the other light rare earth elements and the total amount of light rare earth elements between the two groups. After adjusting for confounding factors, lanthanum (OR=2.91; 95%CI: 1.19-7.10), neodymium (OR=2.14; 95%CI: 1.02-4.51) and small for gestational age infants were still statistically significant. Conclusion: The high concentration of lanthanum and neodymium in the serum of pregnant women is closely related to the occurrence of small for gestational age infants, which will increase the risk of small for gestational age infants.
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