综述

血尿酸与高密度脂蛋白胆固醇比值在心血管疾病中的研究进展*

  • 蔺想军 ,
  • 刘韬 ,
  • 张加春 ,
  • 向佳 ,
  • 何佳琪 ,
  • 朱锋
展开
  • 1.宣汉县人民医院心血管内科,四川达州 636150;
    2.重庆大学附属三峡医院心血管内科
朱锋

收稿日期: 2025-03-16

  网络出版日期: 2026-04-02

基金资助

*四川省医学会伤口/慢病(泰阁)专项科研项目(2024TG55)

Research progress of the uric acid to high-density lipoprotein cholesterol ratio in the cardiovascular diseases

  • LIN Xiangjun ,
  • LIU Tao ,
  • ZHANG Jiachun ,
  • XIANG Jia ,
  • HE Jiaqi ,
  • ZHU Feng
Expand
  • 1. Department of Cardiovascular Medicine, Xuanhan County People′s Hospital, Dazhou 636150, China;
    2. Department of Cardiovascular Medicine, Chongqing University Three Gorges Hospital

Received date: 2025-03-16

  Online published: 2026-04-02

摘要

心血管疾病是当前全球最主要的死亡原因之一。血尿酸水平和高密度脂蛋白胆固醇水平是影响心血管健康的两个重要因素。近期研究发现,血尿酸与高密度脂蛋白胆固醇比值(uric acid to high-density lipoprotein cholesterol ratio,UHR)可以更好地反映心血管疾病的发生风险及预后。本文综述了近年来UHR在心血管疾病中的临床应用价值,为临床诊疗提供参考依据。

本文引用格式

蔺想军 , 刘韬 , 张加春 , 向佳 , 何佳琪 , 朱锋 . 血尿酸与高密度脂蛋白胆固醇比值在心血管疾病中的研究进展*[J]. 包头医学院学报, 2026 , 42(1) : 91 -96 . DOI: 10.16833/j.cnki.jbmc.2026.01.016

Abstract

Cardiovascular disease is one of the leading causes of death in the world. Serum uric acid level and high-density lipoprotein cholesterol level are two important factors affecting cardiovascular health. Recent studies have found that serum uric acid to high-density lipoprotein cholesterol ratio ( UHR ) can better reflect the risk and prognosis of cardiovascular disease. This article reviews the clinical application value of UHR in cardiovascular diseases in recent years, and provides reference for clinical diagnosis and treatment.

参考文献

[1] Wu J, Feng Y, Zhao Y, et al. Lifestyle behaviors and risk of cardiovascular disease and prognosis among individuals with cardiovascular disease:a systematic review and meta-analysis of 71 prospective cohort studies[J]. Int J Behav Nutr Phys Act, 2024, 21(1): 42.
[2] 中国心血管健康与疾病报告编写组.中国心血管健康与疾病报告2022概要[J]. 中国循环杂志, 2023, 38(6): 583-612.
[3] Chen F, He Z, Wang C, et al. Advances in the study of S100A9 in cardiovascular diseases[J]. Cell Prolif, 2024, 57(8): e13636.
[4] Gan T, Ye Y, Mo G, et al. Progress of uric acid in cardiovascular disease[J]. Cardiovasc Endocrinol Metab, 2024, 13(2): e300.
[5] Yu W, Cheng J. Uric acid and cardiovascular disease: an update from molecular mechanism to clinical perspective[J]. Front Pharmacol, 2020, 11: 582680.
[6] Ko J, Kang H, Kim D, et al. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding[J]. FASEB J, 2019, 33(12): 13334-13345.
[7] Ando K, Takahashi H, Watanabe T, et al. Impact of serum uric acid levels on coronary plaque stability evaluated using integrated backscatter intravascular ultrasound in patients with coronary artery disease[J]. J Atheroscler Thromb, 2016, 23(8): 932-939.
[8] Nofer J, van der Giet M, Tölle M, et al. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3[J]. J Clin Invest, 2004, 113(4): 569-581.
[9] Li P, Zhang L, Zhang M, et al. Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress: a mechanism for uric acid-induced endothelial dysfunction[J]. Int J Mol Med, 2016, 37(4): 989-997.
[10] Hu X, Liu J, Li W, et al. Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis[J]. Nutr Metab Cardiovasc Dis, 2022, 32(7): 1661-1669.
[11] Yan L, Hu X, Wu S, et al. Association of platelet to high-density lipoprotein cholesterol ratio with hyperuricemia[J]. Sci Rep, 2024, 14(1): 15641.
[12] 张雪晴, 陈树春. 血尿酸与高密度脂蛋白胆固醇比值在糖脂代谢相关疾病中的研究进展[J]. 临床荟萃, 2022, 37(11): 1044-1047.
[13] Xuan Y, Zhang W, Wang Y, et al. Association between uric acid to HDL cholesterol ratio and diabetic complications in men and postmenopausal women[J]. Diabetes Metab Syndr Obes, 2023, 16: 167-177.
[14] Nagao M, Nakajima H, Toh R, et al. Cardioprotective effects of high-density lipoprotein beyond its anti-atherogenic action[J]. J Atheroscler Thromb, 2018, 25(10): 985-993.
[15] Linton MF, Yancey PG, Tao H, et al. HDL function and atherosclerosis: reactive dicarbonyls as promising targets of therapy[J]. Circ Res, 2023, 132(11): 1521-1545.
[16] Franczyk B, Rysz J, Ławiński J, et al. Is a high HDL-cholesterol level always beneficial[J]. Biomedicines, 2021, 9(9): 1083.
[17] Zhou X, Xu J. Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and insulin resistance in an American population: A population-based analysis[J]. J Diabetes Investig, 2024, 15(6): 762-771.
[18] 齐晨, 关敬元, 王锦溪, 等. 不同血清尿酸水平对心力衰竭患者的预后价值[J]. 中华心力衰竭和心肌病杂志, 2024, 8(1): 2-9.
[19] Aktas G, Khalid A, Kurtkulagi O, et al. Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio:a cross-sectional cohort study[J]. Postgrad Med, 2022, 134(3): 297-302.
[20] Deng F, Jia F, Sun Y, et al. Predictive value of the serum uric acid to high-density lipoprotein cholesterol ratio for culprit plaques in patients with acute coronary syndrome[J]. BMC Cardiovasc Disord, 2024, 24(1): 155.
[21] Liu R, Peng Y, Wu H, et al. Uric acid to high-density lipoprotein cholesterol ratio predicts cardiovascular mortality in patients on peritoneal dialysis[J]. Nutr Metab Cardiovasc Dis: NMCD, 2021, 31(2): 561-569.
[22] Yang Y, Zhang J, Jia L, et al. The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction[J]. Front Cardiovasc Med, 2023, 10: 1226108.
[23] Ahari RK, Sahranavard T, Mansoori A, et al. Association of atherosclerosis indices, serum uric acid to high-density lipoprotein cholesterol ratio and triglycerides-glucose index with hypertension: A gender-disaggregated analysis[J]. J Clin Hypertens(Greenwich), 2024, 26(6): 645-655.
[24] Han X, Tan X, Liu M, et al. Association between serum uric acid/high-density lipoprotein cholesterol ratio and hypertension among reproductive-aged women[J]. J Health Population Nutr, 2023, 42(1): 123.
[25] Zhang H, Dhalla NS. The role of pro-inflammatory cytokines in the pathogenesis of cardiovascular disease[J]. Int J Mol Sci, 2024, 25(2): 1082.
[26] Park B, Jung D, Lee Y. Predictive value of serum uric acid to HDL cholesterol ratio for incident ischemic heart disease in non-diabetic Koreans[J]. Biomedicines, 2022, 10(6): 1422.
[27] Demir ÖF, Arslan A, Kιnιk M, et al. The uric acid/HDL-C ratio may predict significant coronary stenosis in moderate left main coronary artery lesions: an intravascular ultrasonography study[J]. Lipids Health Dis, 2024, 23(1): 233.
[28] Li F, Zhao D, Li Q, et al. Uric acid to high-density lipoprotein cholesterol ratio is a novel marker to predict functionally significant coronary artery stenosis[J]. J Interv Cardiol, 2022, 2022: 9057832.
[29] Aydιn C, Emlek N. The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion[J]. Kardiologiia, 2021, 61(9): 61-65.
[30] Liu G, Zhang Q, Zhou M, et al. Correlation between serum uric acid to high-density lipoprotein cholesterol ratio and atrial fibrillation in patients with NAFLD[J]. PloS one, 2024, 19(6): e305952.
[31] Xu J, Du X, Zhang S, et al. Diagnostic value of uric acid to high-density lipoprotein cholesterol ratio in abdominal aortic aneurysms[J]. Ann Med, 2024, 56(1): 2357224.
[32] Wang H, Ba Y, Gao X, et al. Association between serum uric acid to high density lipoprotein-cholesterol ratio and arterial stiffness in a Japanese population[J]. Medicine, 2023, 102(31): e34182.
文章导航

/