Objective: To analyze the expression and clinical value of circGRHPR in peripheral blood of patients with atherosclerotic cerebral infarction. Methods: A total of 81 patients diagnosed with atherosclerotic cerebral infarction from June 2021 to October 2024 were used as the experimental group, and 81 healthy subjects were used as the control group. The clinical data of the experimental group and the control group were collected, including gender, age, history of disease, history of tobacco and alcohol, blood biochemical indicators, etc. The copy number of circGRHPR in peripheral blood was calculated by quantitative PCR. Pearson correlation was used to analyze the correlation between circGRHPR and atherosclerosis cerebral infarction, and Logistic regression analysis was used to analyze the independent risk factors of atherosclerosis cerebral infarction. Results: There were significant differences in blood pressure, cholesterol level, high-density lipoprotein level and drinking history between the two groups (P＜0.05). The expression level of circGRHPR in peripheral blood of patients in the experimental group was significantly higher than that in the control group (P＜0.05). Gender, age, systolic blood pressure, diastolic blood pressure, cholesterol level, history of hypertension, smoking history, drinking history and expression level of circGRHPR in peripheral blood were positively correlated with the occurrence of atherosclerotic cerebral infarction (P＜0.05). There was no collinearity relationship among variables in collinearity statistics. The area under the curve of the expression level of circGRHPR in peripheral blood of patients with atherosclerotic cerebral infarction was 0.692, the sensitivity was 0.92, and the specificity was 0.51. Binary Logistic regression analysis showed that the independent risk factors of patients were gender, age, systolic blood pressure, diastolic blood pressure, history of hypertension, smoking history, drinking history and circGRHPR expression level in peripheral blood (P＜0.05). Conclusion: circGRHPR expression in peripheral blood of patients with atherosis cerebral infarction is up-regulated, which can be used as an ideal biomarker for the diagnosis of atherosis cerebral infarction, and may also be a potential target for therapeutic intervention.
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