[1] Tang X, Jiang L, Luo Y, et al. Leukoaraiosis and acute ischemic stroke[J]. Eur J Neurosci, 2021, 54(6): 6202-6213.
[2] Kalogeris T, Baines CP, Krenz M, et al. Cell biology of ischemia/reperfusion injury[J]. Int Rev Cell Moi Biol, 2012, 298: 229-317.
[3] Datta A, Sarmah D, Mounica L, et al. Cell death pathways in ischemic stroke and targeted pharmacotherapy[J]. Transl Stroke Res, 2020, 11(6): 1185-1202.
[4] Zheng H, Xiao X, Han Y, et al. Research progress of propofol in alleviating cerebral ischemia/reperfusion injury[J]. Pharmacol Rep, 2024, 76(5): 962-980.
[5] Colonna M, Butovsky O. Microglia function in the central nervous system during health and neurodegeneration[J]. Annu Rev Immunol, 2017, 35: 441-468.
[6] Yusuying S, Yusuyin S, Cheng X. Translocator protein regulate polarization phenotype transformation of microglia after cerebral ischemia-reperfusion injury[J]. Neuroscience, 2022, 480: 203-216.
[7] Qiao C, Liu Z, Qie S. The implications of microglial regulation in neuroplasticity-dependent stroke recovery[J]. Biomolecules, 2023, 13(3): 571.
[8] Wang L, Ren W, Wu Q, et al. NLRP3 inflammasome activation: a therapeutic target for cerebral ischemia-reperfusion injury[J]. Front Mol Neurosci, 2022, 15: 847440.
[9] Chen Y, Tang Y, Tong X, et al. Protective effects of P2X7 receptor inhibition in cerebral ischemia/reperfusion injury in rats[J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2018, 43(11): 1169-1176.
[10] Su JH, Wu GP, Peng X, et al. Neuroprotective effects of an N-salicyloyl tryptamine derivative against cerebral ischemia/reperfusion injury[J]. Acs Chem Neurosci, 2023, 14(11): 2146-2158.
[11] Ran Y, Qie S, Gao F, et al. Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway[J]. Brain Res, 2021, 1770: 147626.
[12] Zhang X, Zhang Q, Huang L, et al. Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway[J]. Pharm Biol, 2021, 59(1): 826-837.
[13] Tian R, Wu B, Fu C, et al. miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke[J]. Aging(albany NY), 2020, 12(11): 10873.
[14] Lu J, Wang J, Yu L, et al. Shaoyao-Gancao decoction promoted microglia M2 polarization via the IL-13-mediated JAK2/STAT6 pathway to alleviate cerebral ischemia-reperfusion injury[J]. Mediators Inflamm, 2022, 2022(1): 1707122.
[15] Zhu F, Xiong J, Yi F, et al. Albiflorin relieves cerebral ischemia-reperfusion injury by activating Nrf2/HO-1 pathway[J]. Histol Histopathol,2023,38(2):233-245.
[16] Qiu M, Xu E, Zhan L. Epigenetic regulations of microglia/macrophage polarization in ischemic stroke[J]. Front Mol Neurosci, 2021, 14: 697416.
[17] Guo ML, Periyasamy P, Liao K, et al. Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation[J]. Epigenetics, 2016, 11(11): 819-830.
[18] Periyasamy P, Thangaraj A, Guo ML, et al. Epigenetic promoter DNA methylation of miR-124 promotes HIV-1 Tat-mediated microglial activation via MECP2-STAT3 axis[J]. J Neurosci, 2018, 38(23): 5367-5383.
[19] Patnala R, Arumugam TV, Gupta N, et al. HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke[J]. Mol Neurobiol, 2017, 54(8): 6391-6411.
[20] Li S, Lu X, Shao Q, et al. Early histone deacetylase inhibition mitigates ischemia/reperfusion brain injury by reducing microglia activation and modulating their phenotype[J]. Front Neurol, 2019, 10: 893.
[21] Arifuzzaman S, Das A, Kim SH, et al. Selective inhibition of EZH2 by a small molecule inhibitor regulates microglial gene expression essential for inflammation[J]. Biochem Pharmacol, 2017, 137: 61-80.
[22] Chen J, Zhang M, Zhang X, et al. EZH2 inhibitor DZNep modulates microglial activation and protects against ischaemic brain injury after experimental stroke[J]. Eur J Pharmacol, 2019, 857: 172452.
[23] Alexaki VI, Fodelianaki G, Neuwirth A, et al. DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway[J]. Mol Psychiatry, 2018, 23(6): 1410-1420.
[24] Gao WM, Chadha MS, Kline AE, et al. Immunohistochemical analysis of histone H3 acetylation and methylation—evidence for altered epigenetic signaling following traumatic brain injury in immature rats[J]. Brain Res, 2006, 1070(1): 31-34.
[25] Brookes RL, Crichton S, Wolfe CDA, et al. Sodium valproate, a histone deacetylase inhibitor, is associated with reduced stroke risk after previous ischemic stroke or transient ischemic attack[J]. Stroke, 2018,49(1):54-61.
[26] Dubey H, Gulati K, Ray A. Alzheimer's disease: A contextual link with nitric oxide synthase[J]. Curr Mol Med, 2020, 20(7): 505-515.
[27] Kao MH, Wu JS, Cheung WM, et al. Clinacanthus nutans mitigates neuronal death and reduces ischemic brain injury: Role of NF-κB-driven IL-1β transcription[J]. Neuromolecular Med, 2021, 23(1): 199-210.
[28] Victoria ECG, de Brito Toscano EC, Oliveira FMS, et al. Up-regulation of brain cytokines and metalloproteinases 1 and 2 contributes to neurological deficit and brain damage in transient ischemic stroke[J]. Microvasc Res, 2020, 129: 103973.
[29] Wang S, Liang R, Liu H. Phoenixin-20 ameliorates brain infarction by promoting microglia M2 polarization in an ischemic stroke model[J]. Metab Brain Dis, 2022, 37(5): 1517-1526.
[30] Chen M, Chen Q, Tao T. Tanshinone IIA promotes M2 microglia by erβ/IL-10 pathway and attenuates neuronal loss in mouse TBI model[J]. Neuropsychiatr Dis Treat, 2020,16: 3239-3250.
[31] Collmann FM, Pijnenburg R, Hamzei-Taj S, et al. Individual in vivo profiles of microglia polarization after stroke, represented by the genes iNOS and Ym1[J]. Front Immunol, 2019, 10: 1236.
[32] You S, Ma Z, Zhang P, et al. Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia[J]. Biomed Pharmacother, 2024, 174: 116460.
[33] Hu Y, Tao W. Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction[J]. J Adv Res, 2024, 66: 251-265.
[34] Liu L, Liu X, Wang R, et al. Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice[J]. Neurol Res, 2018, 40(6): 508-515.
[35] Chen X, Yao J, Lai J, et al. ADAM17 aggravates the inflammatory response by modulating microglia polarization through the TGF-β1/smad pathway following experimental traumatic brain injury[J]. J Neurotrauma, 2023, 40(13-14): 1495-1509.
[36] Sun XR, Yao ZM, Chen L, et al. Metabolic reprogramming regulates microglial polarization and its role in cerebral ischemia reperfusion[J]. Fundam Clin Pharmacol, 2023, 37(6): 1065-1078.
[37] Wang S, Pan Y, Zhang C, et al. Transcriptome analysis reveals dynamic microglial-induced A1 astrocyte reactivity via C3/C3aR/NF-κB signaling after ischemic stroke[J]. Mol Neurobiol, 2024, 61(12): 10246-10270.
[38] Goussakov I, Synowiec S, Aksenov DP, et al. Occlusion of activity dependent synaptic plasticity by late hypoxic long term potentiation after neonatal intermittent hypoxia[J]. Exp Neurol, 2021, 337: 113575.
[39] Cheng Z, Shao W, Wei C, et al. Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury[J]. ACS Nano, 2025, 19(10): 10529-10548.
[40] Choi IA, Yun J H, Lee J, et al. Neuropeptide FF Promotes Neuronal Survival and Enhances Synaptic Protein Expression Following Ischemic Injury[J]. Int J Mol Sci, 2024, 25(21): 11580.
[41] Zhao X, Wang Z, Wang J, et al. Mesencephalic astrocyte-derived neurotrophic factor(MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway[J]. Int Immunopharmacol, 2024, 127: 111396.
[42] Xiang X, Tang X, Yu Y, et al. Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia[J]. J Neuroinflammation, 2022, 19(1): 92.
[43] Wang H, Liu X, Chen Y, et al. The regulatory role of miR-21 in ferroptosis by targeting FTH1 and the contribution of microglia-derived miR-21 in exosomes to arsenic-induced neuronal ferroptosis[J]. J Hazard Mater, 2024, 478: 135580.
[44] Weilinger NL, Yang K, Choi HB, et al. Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts[J]. Cell Rep, 2023, 42(10):113128.
[45] Lauro C, Chece G, Monaco L, et al. Fractalkine modulates microglia metabolism in brain ischemia[J]. Front Cell Neurosci, 2019, 13: 414.
