目的: 分析包头市养殖人员中戊型肝炎病毒(HEV)感染的流行病学特点,评估不同年龄组养殖人群的感染率,为该养殖人群预防和控制戊型肝炎提供数据支持。方法: 2023年7月至2024年7月期间收集包头市养殖(猪、牛、羊)人员的血样标本,通过ELISA法检测血清中HEV-IgG抗体。研究样本根据年龄分组,并统计各年龄组的感染阳性率。结果: 共收集样本679例,各年龄组感染阳性率分别为:0岁至≤20岁组3.23%,＞20岁且≤30岁组10.87%,＞30岁且≤40岁组14.93%,＞40岁且≤50岁组41.28%,＞50岁且≤60岁组50.00%,＞60岁且≤70岁组34.52%,＞70岁且≤80岁组68.57%,＞80岁且≤90岁组60.00%。卡方检验结果显示,＞30岁且≤40岁、＞40岁且≤50岁、＞50岁且≤60岁、＞70岁且≤80岁和＞80岁且≤90岁的感染阳性率与其他年龄组相比具有显著性差异(P＜0.001)。结论: 包头市养殖人群中HEV感染阳性率较高,尤其在40岁以上的群体中更为显著,提示该地区养殖人群可能面临较高的HEV暴露风险,需加强该病毒的防控。
张宇
,
刘锦龙
,
赵建军
,
赵颖
,
王树鹏
,
王延婷
,
魏一依
,
杨永华
,
王佳乐
,
张玉杰
,
白慧敏
. 包头市养殖人群戊型肝炎病毒感染的流行病学分析*[J]. 包头医学院学报, 2025
, 41(12)
: 1
-5
.
DOI: 10.16833/j.cnki.jbmc.2025.12.001
Objective: To analyze the epidemiological characteristics of hepatitis E virus (HEV) infection among aquaculture population in Baotou City, and to evaluate the infection rate of different age groups, so as to provide data support for the prevention and control of hepatitis E in the aquaculture population. Methods: Blood samples of aquaculture population (pigs, cattle, sheep) in Baotou City from July 2023 to July 2024 were collected, and HEV-IgG antibodies in serum were detected by ELISA. Grouped according to the age, and the positive rate of infection in each age group was counted. Results: A total of 679 samples were collected. The positive infection rates of each age group were as follows: the group from 0 to≤20 years was 3.23%,＞20 to≤30 years was 10.87%,＞30 to≤40 years was 14.93%, ＞40 to≤50 years was 41.28%, ＞50 to≤60 years was 50.00%,＞60 to≤70 years was 34.52%, ＞70 to≤80 years was 68.57%, ＞80 to≤90 years was 60.00%. The results of the chi-square test showed that the positive infection rates of the groups ＞30 to≤40 years old,＞40 to≤50 years old, ＞50 to≤60 years,＞70 to≤80 years, and＞80 years to≤90 years were significantly different compared with those of other age groups (P＜0.001). Conclusion: The positive rate of HEV infection in Baotou breeding population is higher, especially in the population over 40 years old, indicating that the aquaculture population may face a higher risk of HEV exposure, and it is necessary to strengthen the prevention and control of this virus.
[1] 张豪锦, 蒋素文, 胡爱荣, 等.戊型肝炎病毒致少见肝外疾病及其致病机制[J].中国人兽共患病学报, 2024, 40(12):1174-1181+1187.
[2] 刘宇轩, 洪萍, 蔡斌, 等.EB病毒感染合并HEV抗体阳性1例并文献复习[J].中国现代医生, 2024, 62(31):131-133,136.
[3] 陈炎玲.甲型肝炎病毒和戊型肝炎病毒免疫球蛋白抗体与肝功能指标表达水平[J].中国医药指南, 2024, 22(29):48-50.
[4] 孙通宝, 吴晨雨, 任照文, 等.野生反刍动物戊型肝炎病毒流行病学研究进展[J].中国兽医学报, 2024, 44(10):2301-2308.
[5] Aslan AT, Balaban HY. Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment[J]. World J Gastroenterol, 2020, 26(37):5543-5560.
[6] 何振文, 刘丁语, 刘宝玲, 等.RNA依赖性RNA聚合酶作为抗戊型肝炎病毒药物作用靶点的研究进展[J].中国畜牧兽医, 2024, 51(10):4568-4577.
[7] 张巧玲, 杨林鹏, 张志豪, 等.吐温80对戊型肝炎病毒病毒样颗粒稳定性的研究[J].微生物学免疫学进展, 2024, 52(5):32-38.
[8] 邓浩辉, 梁淑珍, 刘惠媛.初始抗戊型肝炎病毒免疫球蛋白M阴性的3例戊型肝炎病毒感染者临床特点分析[J].中国肝脏病杂志(电子版), 2024, 16(3):69-72.
[9] 张煜朵, 张亚文, 王金金, 等.禽戊型肝炎病毒与鸡传染性贫血病毒早期共感染SPF鸡的致病性观察[J].中国家禽, 2025, 47(2):66-74.
[10] 李素萍, 胡晓玉, 方烨, 等.献血者HEV感染合并HBV感染的特征分析[J].临床输血与检验, 2024, 26(4):505-510.
[11] 黄芬, 夏月平, 李云龙, 等.稳定表达eGFP-戊型肝炎病毒复制子的建立及体内外特征(英文)[J].昆明理工大学学报(自然科学版), 2024, 49(3):202-217.
[12] 张玉倩, 李长乐, 吕志航, 等.禽戊型肝炎病毒CaHEV-GDSZ01株ORF3蛋白的原核表达及其多克隆抗体的制备[J].华北农学报, 2024, 39(3):224-229.
[13] 曾志伟, 韩腾伟, 王加熊, 等.福建省龙岩市啮齿动物携带戊型肝炎病毒和温州病毒调查及基因特征[J].海峡预防医学杂志, 2024, 30(3):1-4.
[14] Songtanin B, Molehin AJ, Brittan K, et al. Hepatitis E Virus Infections: Epidemiology, Genetic Diversity, and Clinical Considerations[J]. Viruses,2023,15(6):1389.
[15] 汤婷, 田秀颖, 邓宛心, 等.海南鼠戊型肝炎病毒基因遗传进化分析[J].海南医学院学报, 2024, 30(20):1521-1526.
[16] Borlang J, Murphy D, Harlow J, et al.The Molecular Epidemiology of Hepatitis E Virus genotype 3 in Canada[J].Epidemiol Infect, 2024, 152(55):21-24.
[17] Zhang J, Zheng Z, Xia N. Prophylactic Hepatitis E Vaccine[J]. Adv Exp Med Biol, 2023, 1417:227-245.
