目的: 分析PubMed中治疗皮瓣缺血再灌注损伤的研究文献,总结其研究现状和特点,为其研究提供新的依据。方法: 在PubMed中检索2002年1月至2022年4月期间发表的所有治疗皮瓣缺血再灌注损伤文献为335篇,采用CiteSpace软件进行作者、国家、关键词共现分析。结果: 共纳入文章335篇,发文量最多的作者为GÜNTER GERMANN,发文量最多的国家为美国、中国、土耳其、德国等。关键词聚类为肌皮瓣“musculocutaneous flap”,随意皮瓣存活“random flap survival”,高压氧“hyperbaric oxygen”,皮瓣“cutaneous flaps”,游离皮瓣“free flap”,皮瓣“skin flap”,缺血再灌注损伤“ischemia-reperfusion injury”。结论: 对于皮瓣缺血再灌注损伤领域目前研究热点是随意皮瓣存活及高压氧,近几年出现的一氧化氮为治疗皮瓣缺血再灌注损伤的热点。
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