目的: 探讨子宫肌瘤及子宫腺肌瘤患者与ABO血型的相关性。方法: 本研究选取2019年1月至2024年11月在乌兰察布市中心医院及其分院确诊的294例子宫肌瘤患者和151例子宫腺肌瘤患者作为研究对象,进行回顾性分析。同时,选取6 484例健康女性献血者作为对照组。采用病例对照关联研究的方法,分析比较3组研究对象的血型分布情况。结果: 子宫肌瘤组血型表现型频率顺序为B(33.7%)＞O(31.0%)＞A(23.8%)＞AB(11.6%),基因频率顺序为r＞q＞p。子宫腺肌瘤组血型表现型频率顺序为O(37.1%)＞B(31.1%)＞A(25.2%)＞AB(5.6%);基因频率顺序为r＞q＞p。子宫肌瘤组和子宫腺肌瘤组血型及基因频率与健康对照组比较差异均无统计学意义(子宫肌瘤组血型:P=0.590;子宫腺肌瘤组血型:P=0.377;子宫肌瘤组基因频率:P=0.675;子宫腺肌瘤组基因频率:P=0.073)。结论: 子宫肌瘤及子宫腺肌瘤的发病与ABO血型无显著相关性。
Objective: To investigate the correlation between ABO blood type and patients with uterine fibroids and uterine adenomyoma. Methods: The clinical data of 294 patients with uterine fibroids and 151 patients with uterine adenomyoma diagnosed in Ulanqab Central Hospital and its branches from January 2019 to November 2024 were retrospectively analyzed. At the same time, 6 484 healthy female donors were selected as the control group. The blood group distribution of the three groups was analyzed and compared by case-control association study. Results: In the uterine leiomyoma group, the order of blood type phenotype frequencies was B(33.7%)＞O(31.0%)＞A(23.8%)＞AB(11.6%), and the order of gene frequencies was r＞q＞p. In the adenomyosis group, the order of blood type phenotype frequencies was O (37.1%)＞B(31.1%)＞A(25.2%)＞AB(5.6%), and the order of gene frequencies was r＞q＞p. There were no statistically significant differences in blood type and gene frequency among the uterine leiomyoma group, the adenomyoma group, and the healthy control group (blood type of uterine fibroids group: P=0.590, blood type of uterine adenomyoma group:P=0.377, gene frequency of uterine leiomyoma group: P=0.675, gene frequency of uterine adenomyoma group: P=0.073). Conclusion: There is no significant correlation between the occurrence of uterine leiomyoma or adenomyosis and ABO blood type.
[1] 张雅倩. 彩色多普勒超声在子宫肌瘤与子宫腺肌症的诊断与鉴别诊断中的应用效果[J]. 实用妇科内分泌电子杂志, 2021, 8(16): 116-118.
[2] 苟再兴, 唐丽娜. 子宫腺肌瘤和子宫肌瘤应用经阴道彩色多普勒超声诊断的效果分析[J]. 影像研究与医学应用, 2023, 7(22): 116-118.
[3] Giuliani E, As-Sanie S, Marsh EE. Epidemiology and management of uterine fibroids[J]. Int J Gynaecol Obstet, 2020, 149(1): 3-9.
[4] Franchini M, Mengoli C, Lippi G. Relationship between ABO blood group and pregnancy complications:a systematic literature analysis[J]. Blood Transfus, 2016, 14(5): 441-448.
[5] Mandato VD, Torricelli F, Mastrofilippo V, et al. ABO/Rh blood group and cervical cancer survival:results from our own and other studies[J]. J Cancer, 2024, 15(15): 4777-4788.
[6] Wang C, Zhou J, Wang L, et al. ABO blood groups and expression of blood group antigens of epithelial ovarian cancer in Chinese women[J]. Cancer Med, 2023, 12(6): 7498-7507.
[7] 孙平. 妇科肿瘤与ABO血型相关性探讨[J]. 中国卫生标准管理, 2020, 11(19): 131-133.
[8] 戴旭萍, 卢莎, 楼向明, 等. 子宫肌瘤患者ABO血型分布情况分析[J]. 浙江临床医学, 2018, 20(12): 1985-1988.
[9] 金晨, 郭斐斐, 刘丹. 经阴道彩色多普勒超声结合三维重建技术在子宫肌瘤和子宫腺肌瘤诊断中的应用[J]. 肿瘤基础与临床, 2025, 38(2): 183-186.
[10] 叶应妩, 王毓三, 申子瑜. 全国临床检验操作规程[M]. 3版. 南京: 东南大学出版社, 2006: 246.
[11] Whiteman MK, Kuklina E, Jamieson DJ, et al. Inpatient hospitalization for gynecologic disorders in the United States[J]. Am J Obstet Gynecol, 2010, 202(6): 541.
[12] Merrill RM. Hysterectomy surveillance in the United States, 1997 through 2005[J]. Med Sci Monit, 2008, 14(1): CR24-CR31.
[13] Garcia L, Isaacson K. Adenomyosis:review of the literature[J]. J Minim Invasive Gynecol, 2011, 18: 428-437.
[14] Pavone D, Clemenza S, Sorbi F, et al. Epidemiology and risk factors of uterine fibroids[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 46: 3-11.
[15] Abegaz SB. Human ABO blood groups and their associations with different diseases[J]. Biomed Res Int, 2021, 2021: 6629060.
[16] Alexandra G, Alexandru M, Stefan CF, et al. Blood group type association with head and neck cancer[J]. Hematol Rep, 2022, 14(1): 24-30.
[17] Wei S, Yi T, OuYang Z, et al. Association between ABO blood type and type I endometrial cancer:a retrospective study[J]. J Obstet Gynaecol, 2023, 43(1): 2153026.
[18] Wang C, Zhou J, Wang L, et al. ABO blood groups and expression of blood group antigens of epithelial ovarian cancer in Chinese women[J]. Cancer Med, 2023, 12(6): 7498-7507.
[19] 高静, 杨兰泽, 邱琳, 等. 1831例子宫肌瘤与ABO血型关系的探讨[J]. 洛阳医专学报, 2000, (4): 290-291.
[20] 苏楠. 分析子宫肌瘤患者血清转化生长因子-β3、25-羟维生素D、糖类抗原125、血管内皮生长因子水平及临床意义[J]. 现代医学与健康研究电子杂志, 2025, 9(11): 113-116.
[21] 杜俊平, 梁焱, 王威, 等. 腹部、阴道超声及超声造影在子宫肌瘤及子宫腺肌病诊断鉴别中的应用[J]. 哈尔滨医药, 2025, 45(4): 29-32.
[22] 容雁, 卢燕琼, 张洁清, 等. 雌二醇对子宫内膜癌Ishikawa细胞MAPK通路的激活及增殖的影响[J]. 肿瘤防治研究, 2016, 43(3): 211-215.
[23] Schmitz D, Ek WE, Berggren E, et al. Genome-wide association study of estradiol levels and the causal effect of estradiol on bone mineral density[J]. J Clin Endocrinol Metab, 2021, 106(11): e4471-e4486.
