甘油三酯葡萄糖乘积指数联合系统免疫炎症指数对合并2型糖尿病的冠心病患者冠状动脉狭窄程度的预测价值

齐文华; 韩炜; 杜思雨

doi:10.16833/j.cnki.jbmc.2025.04.011

包头医学院学报 >

2025 , Vol. 41 >Issue 4: 55 - 61

DOI: https://doi.org/10.16833/j.cnki.jbmc.2025.04.011

临床医学论著

甘油三酯葡萄糖乘积指数联合系统免疫炎症指数对合并2型糖尿病的冠心病患者冠状动脉狭窄程度的预测价值

齐文华 ,
韩炜 ,
杜思雨

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1.包头医学院研究生学院,内蒙古包头 014040;
2.包头市中心医院心内科

韩炜

收稿日期: 2024-05-06

网络出版日期: 2025-05-14

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Predictive value of triglyceride glucose product index combined with systemic immune inflammation index for coronary artery stenosis in patients with coronary heart disease complicated with type 2 diabetes mellitus

QI Wenhua ,
HAN Wei ,
DU Siyu

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1. Graduate School of Baotou Medical College, Baotou 014040, China;
2. Department of Cardiology, Baotou Central Hospital

Received date: 2024-05-06

Online published: 2025-05-14

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摘要

目的：探讨甘油三酯葡萄糖乘积指数(triglyceride glucose product Index, TyG)联合系统免疫炎症指数(systemic immune inflammation index, SII)对合并2型糖尿病(type 2 diabetes mellitus, T2DM)的冠心病(coronary atherosclerotic heart disease, CAD)患者冠脉狭窄程度的预测价值。方法：选取2022年12月至2023年12月收治于内蒙古包头市中心医院心内科行冠脉造影检查符合CAD诊断标准的T2DM患者(246例)作为研究对象,依据Gensini评分中位数法,将其分为低狭窄组(≤23)126例与高狭窄组(＞23)120例。构建多因素Logistic回归分析TyG指数、SII等指标与合并T2DM的CAD患者冠脉狭窄程度的相关性,并构建联合方程,绘制单个和多个指标联合的ROC曲线,报告曲线下面积,评估TyG指数、SII以及二者联合系数对合并T2DM的CAD患者冠脉狭窄程度的预测价值。结果：多因素Logistic回归分析显示,吸烟史、高血压病史、TyG指数、SII是合并T2DM的CAD患者冠脉狭窄程度的独立危险因素。以TyG指数和SII的联合系数绘制ROC曲线下面积AUC=0.723 [95% CI (0.661-0.785),P＜0.05],提示预测能力尚佳。结论：TyG指数、SII是合并T2DM的CAD患者冠脉狭窄程度的独立危险因素。TyG指数联合SII可以较好地预测合并T2DM的CAD患者的冠脉狭窄程度。

关键词： 甘油三酯葡萄糖乘积指数; 系统免疫炎症指数; 冠心病; 2型糖尿病; 冠状动脉狭窄程度

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齐文华 , 韩炜 , 杜思雨 . 甘油三酯葡萄糖乘积指数联合系统免疫炎症指数对合并2型糖尿病的冠心病患者冠状动脉狭窄程度的预测价值[J]. 包头医学院学报, 2025 , 41(4) : 55 -61 . DOI: 10.16833/j.cnki.jbmc.2025.04.011

Abstract

Objective:To investigate the predictive value of triglyceride glucose product index (TyG) combined with systemic immune inflammation index (SII) on the degree of coronary artery stenosis in patients with coronary heart disease (CAD) complicated with type 2 diabetes mellitus (T2DM). Methods: From December 2022 to December 2023, 246 patients with T2DM who were admitted to the Department of Cardiology of Baotou Central Hospital of Inner Mongolia for suspected CAD and underwent coronary angiography during hospitalization and whose results met the diagnostic criteria of CAD were selected as subjects. According to the median Gensini score method, they were divided into low stenosis group (≤23 scores, n=126) and high stenosis group (＞23 scores, n=120). Multivariate logistic regression analysis was used to analyze the correlation between TyG index, SII and other indicators and the degree of coronary artery stenosis in CAD patients with T2DM, and the combined equation was constructed, the ROC curves of single and multiple indicators were drawn, the area under the curve was reported to further evaluate the predictive value of TyG index, SII and the combined coefficient of the two for the degree of coronary stenosis in CAD patients with T2DM. Results: Multivariate Logistic regression analysis showed that smoking history, history of hypertension, TyG index and SII were independent risk factors for coronary artery stenosis in CAD patients with T2DM. The combined coefficient of TyG index and SII was used to draw the area under the ROC curve AUC=0.723 [95% CI (0.661-0.785), P＜0.05], suggesting that the predictive ability was good. Conclusion: TyG index and SII are independent risk factors for coronary artery stenosis in CAD patients with T2DM. TyG index combined with SII can better predict the degree of coronary artery stenosis in CAD patients with T2DM.

Key words： Triglyceride glucose multiplication index; Systemic immune-inflammatory index; Coronary heart disease; Type 2 diabetes mellitus; Degree of coronary artery stenosis

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