目的：通过临床资料研究心房颤动(AF)与微小非编码RNA-21(miRNA-21)之间的相关性,以期为临床 AF 的诊治提供参考价值。方法：收集2022年09月至2023年12月在天津市某三甲医院心内科住院的患者142例,其中十二导联体表心电图的结果满足“P波消失,代之以大小不等、形态各异的小f波,RR间期绝对不规则”条件的纳入AF 组,70例,其余72例纳入对照组,比较两组患者之间的血浆miRNA-21及心脏超声等各项指标。结果：与对照组比较,AF组利伐沙班、达比加群酯、华法林等抗凝药物以及胺碘酮用药量明显多于对照组(P＜0.05),低密度脂蛋白胆固醇(LDLc)结果相对低(P＜0.05),左房内径较大(P＜0.05),血浆中miRNA-21高表达(P＜0.05)。Logistic回归分析结果显示AF的发生与左房内径、miRNA-21指标有关(P＜0.05)。结论：AF的发生可能与血浆中miRNA-21表达和左房内径大小存在相关性。
Objective:To study the correlation between atrial fibrillation (AF) and micro RNA-21 (miRNA-21) through clinical data, in order to provide reference value for clinical diagnosis and treatment of AF. Methods: A total of 142 patients who were hospitalized in the Department of Cardiology of a tertiary hospital in Tianjin from September 2022 to December 2023 were collected. According to the results of 12-lead surface electrocardiogram, 70 patients who met the conditions of ′P wave disappeared, replaced by small f waves of different sizes and shapes, and RR interval was absolutely irregular′ were included in the AF group, and the remaining 72 patients were included in the control group. Plasma miRNA-21 and echocardiography were compared between the two groups. Results: Compared with the control group, the dosage of anticoagulants such as rivaroxaban, dabigatran etexilate, warfarin and amiodarone in AF group was significantly higher than that in control group (P＜0.05), the level of low density lipoprotein cholesterol (LDLc) was lower (P＜0.05), the diameter of left atrium was larger (P＜0.05), and the expression of miRNA-21 in plasma was higher (P＜0.05). Logistic regression analysis showed that the occurrence of AF was related to left atrial diameter and miRNA-21 indexes (P＜0.05). Conclusion: The occurrence of AF may be correlated with the expression of miRNA-21 in plasma and the size of left atrium.
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