基础医学论著

CD26、CLDN1与甲状腺乳头状癌的相关性研究

  • 张作宇 ,
  • 付福山 ,
  • 杨晓楠 ,
  • 王占龙
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  • 1.包头医学院研究生院, 内蒙古包头 014040;
    2.包头医学院第一附属医院头颈、甲状腺外科
王占龙

收稿日期: 2023-11-02

  网络出版日期: 2024-11-26

Correlation study of CD26、CLDN1 and papillary thyroid cancer

  • ZHANG Zuoyu ,
  • FU Fushan ,
  • YANG Xiaonan ,
  • WANG Zhanlong
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  • 1. Graduate School of Baotou Medical College, Baotou 014040, China;
    2. Department of Head and Neck Thyroid Surgery, the First Affiliated Hospital of Baotou Medical College

Received date: 2023-11-02

  Online published: 2024-11-26

摘要

目的: 探讨CD26及CLDN1在甲状腺乳头状癌(papillary thyroid carcinoma, PTC)防治中的临床应用价值。方法: 选择包头市肿瘤医院2021年12月-2022年12月收治的48例PTC患者病理组织切片标本,将肿瘤组织作为实验组,癌旁组织作为对照组。采用免疫组化法对两组组织中CD26、CLDN1表达水平进行测定,采用SPSS 27.0分析PTC患者组织中CD26、CLDN1与临床病理之间的关系,各组数据阳性率间的相关性采用Spearman相关分析检验(α=0.05)。结果: 癌组织CD26、CLDN1阳性表达率分别为85.42%、83.33%,高于癌旁组的27.08%和20.83%,差异均有统计学意义(P<0.05); 在不同PTC患者年龄、性别、最大肿瘤直径、单侧、双侧甲状腺腺叶上的肿瘤、有无侵犯包膜,CD26、CLDN1蛋白阳性表达率差异无统计学意义(均P>0.05)。CD26、CLDN1与淋巴结转移均存在相关性(P<0.05);CD26与CLDN1在PTC组织中表达有明显的正相关性(rs=0.294,P<0.05)。结论: CD26、CLDN1在PTC发生发展中扮演重要角色,联合检测这两种蛋白有助于PTC的诊断和治疗。

本文引用格式

张作宇 , 付福山 , 杨晓楠 , 王占龙 . CD26、CLDN1与甲状腺乳头状癌的相关性研究[J]. 包头医学院学报, 2024 , 40(11) : 46 -49 . DOI: 10.16833/j.cnki.jbmc.2024.11.010

Abstract

Objective: To investigate the clinical value of CD26 and CLDN1 in the prevention and treatment of papillary thyroid carcinoma (PTC). Methods: Pathological tissue section specimens of 48 surgical patients with PTC admitted to Baotou Cancer Hospital from December 2021 to December 2022 were selected, with tumor tissues as the experimental group and adjacent tissues as the control group. The expression levels of CD26 and CLDN1 in the two groups were measured by immunohistochemistry. SPSS 27.0 was used to analyze the relationship between CD26, CLDN1 and clinicopathology in PTC patients. The correlation between the positive rates of each group was tested by Spearman correlation analysis (α=0.05). Results: The positive expression rates of CD26 and CLDN1 in tumor tissues were 85.42% and 83.33%, respectively, which were higher than 27.08% and 20.83% in adjacent tissues, and the differences were statistically significant (P<0.05). There was no significant difference in the positive expression rate of CD26 and CLDN1 protein in different PTC patients with different age, gender, maximum tumor diameter, unilateral, bilateral thyroid gland tumors, and invasion of the capsule (all P>0.05). CD26 and CLDN1 were correlated with lymph node metastasis(P<0.05). There was a significant positive correlation between the expression of CD26 and CLDN1 in PTC tissues (rs=0.294, P<0.05). Conclusion: CD26 and CLDN1 play an important role in the occurrence and development of PTC. Combined detection of CD26 and CLDN1 is helpful to the diagnosis and treatment of PTC.

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