目的: 探讨肾上腺髓质素(adrenomedullin, ADM)基因在肝癌中的表达及对肝癌患者生存预后的影响。方法: 利用Kaplan-Meier Plotter数据库分析ADM的表达对肝癌患者总生存期及无进展生存期的影响。结果: BioGPS数据库中ADM在人体正常肝组织中低表达(16.90±0.00);Oncomine数据库检索出ADM基因的研究共有425项,表达差异有统计学意义的研究有43项,其中高表达有22项,低表达有21项;Kaplan-Meier Plotter数据库结果表明ADM高表达组的患者总体生存时间(overall survival, OS)及无进展生存时间(progression-freesurvival, PFS)较低表达组明显缩短(P＜0.001)。结论: ADM基因在肝癌组织中呈高表达,且与肝癌患者预后有关,有望为肝癌治疗及预后判断提供重要依据。
Objective: To investigate the expression of adrenomedullin (ADM) gene in liver cancer and its effect on the survival and prognosis. Methods: Kaplan-Meier Plotter database was used to analyze the effect of ADM gene expression on overall survival and progression-free survival of patients with liver cancer. Results: The ADM gene in BioGPS database was lowly expressed in human normal liver tissue (16.90±0.00). A total of 425 studies on ADM gene were retrieved from the Oncomine database, while there were 43 studies with statistically significant differential expression, of which 22 studies were highly expressed and 21 studies were lowly expressed. Kaplan-Meier Plotter database results showed that the overall survival (OS) and progression-free survival (PFS) of patients in the ADM high expression group were significantly shorter than those in the low expression group (P＜0.001). Conclusion: ADM is highly expressed in liver cancer tissue, and the ADM expression is related to the prognosis of liver cancer patients. It is expected to provide an important basis for the treatment and prognosis of liver cancer.
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