目的:系统评价中国中老年人群高尿酸血症(hyperuricemia,HUA)危险因素。方法:计算机检索Embase、Web of Science、Pubmed、The Cochrane Library、中国知网(CNKI)、万方数据库(Wangfang data)、中国生物医学文献数据库(CBM)、维普数据库(VIP)等数据库,收集有关中国中老年人群HUA危险因素的文献,检索时限为建库至2022年3月。采用RevMan 5.3软件和Stata 14.0软件进行Meta分析。结果:共纳入20篇文献,包括72 020例HUA患者,Meta分析结果显示,高血压(OR=1.43,95%CI:1.26~1.62),年龄≥45岁(OR=1.11,95%CI:1.07~1.15),饮酒(OR=1.47,95%CI:1.31~1.65),高体质指数(body mass index,BMI)(OR=1.06,95%CI:1.02~1.19),高甘油三酯(triglyceride,TG)(OR=1.81,95%CI:1.58~2.07),肾功能不全(OR=2.88,95%CI:1.76~4.73),高胆固醇(total cholesterol,TC)(OR=1.21,95%CI:1.09~1.33),高血肌酐(OR=1.69,95%CI:1.53~1.85),中心性肥胖(OR=1.52,95%CI:1.30~1.79)和高尿素氮(OR=1.53,95%CI:1.23~1.90)是中国中老年人群HUA危险因素(P＜0.05);高密度脂蛋白(high density lipoprotein,HDL-C)(OR=0.50,95%CI:0.36~0.70)和高血糖(OR=0.75,95%CI:0.66~0.86)是中国中老年人群HUA保护因素(P＜0.05)。结论:高血压、年龄≥45岁、饮酒、高BMI、高TG、肾功能不全、高TC、高血肌酐、中心性肥胖、高尿素氮是中国中老年人群HUA危险因素,高血糖和HDL-C是中国中老年人群HUA保护因素。
Objective:To systematically evaluate the risk factors of hyperuricemia (HUA) in middle-aged and elderly people in China. Methods:The Embase,Web of Science,PubMed,the Cochrane Library,Chinese National Knowledge Infrastructure (CNKI),Wangfang Data,Chinese Biomedical Literature Database (CBM),and VIP database were selected to collect literaturse on risk factors of HUA in middle-aged and elderly people in China. The retrieval time limitation was defined from the establishment of the database until March 2022. RevMan 5.3 and Stata 14.0 software were used for data analysis. Results:A total of 20 studies were included,including 72 020 cases of HUA patient. Meta-analysis results showed that hypertension (OR=1.43,95%CI: 1.26-1.62),age ≥45 (OR=1.11,95%CI: 1.07-1.15),alcohol consumption (OR=1.47,95%CI: 1.31-1.65),high body mass index (BMI) (OR=1.06,95%CI: 1.02-1.19),high triglyceride (TG) (OR=1.81,95%CI: 1.58-2.07),renal insufficiency (OR=2.88,95%CI: 1.76~4.73),high cholesterol (TC) (OR=1.21,95%CI: 1.09~1.33),high serum creatinine (OR=1.69,95%CI: 1.53~1.85),central obesity (OR=1.52,95%CI: 1.30-1.79) and high urea nitrogen (OR=1.53,95%CI: 1.23-1.90) were risk factors for HUA in middle-aged and elderly people in China. High density lipoprotein (HDL-C) (OR=0.50,95%CI:0.36~0.70) and hyperglycemia (OR=0.75,95%CI: 0.66-0.86) were protective factors to HUA in middle-aged and elderly people in China. Conclusion:Hypertension,age ≥45 years,alcohol consumption,high BMI,high TG,renal insufficiency,high TC,high serum creatinine,central obesity and high urea nitrogen are the risk factors for HUA in middle-aged and elderly people in China. Meanwhile,high blood glucose and HDL-C are the protective factors to HUA.
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