目的: 调查内蒙古包头市区儿童青少年高尿酸血症(HUA)患病情况及相关因素。方法: 收集2021年1月至2022年6月就诊于包头市三区三级医院儿科、风湿免疫科的3～18岁儿童青少年资料,将其中符合研究标准的作为研究对象,整理资料并对结果进行统计分析。结果: 不同性别、年龄段之间SUA水平差异有统计学意义(P＜0.05);在3～6岁,7～9岁,10～18岁年龄段,男生HUA检出率分别为4.93%,3.21%,4.41%,女生HUA检出率分别为4.44%,3%,2%;在男生中,HUA组与正常组的尿素氮(BUN)、肌酐(Cr)、天门冬氨酸氨基转移酶(AST)、血糖(Glu)、血脂水平差异有统计学意义(P＜0.05);在女生中,HUA组与正常组的AST水平差异有统计学意义(P＜0.05)。相关性分析结果显示,男生SUA水平与尿素氮(BUN)、肌酐(Cr)、丙氨酸氨基转移酶(ALT)、甘油三酯(TG)、总胆固醇(TC)呈正相关(P＜0.05);女生SUA水平与Glu呈负相关(P＜0.05),与BUN、Cr、ALT呈正相关(P＜0.05)。多因素Logistic回归分析结果显示,BUN、TC是男生HUA的影响因素,Glu是女生HUA的影响因素 。结论: 包头市区儿童青少年血尿酸水平在不同年龄和性别中存在差异,男生高尿酸血症检出率较女生高;高尿酸血症可引起BUN、Cr、AST、Glu、血脂水平变化;TC、BUN、Glu是儿童青少年高尿酸血症的影响因素。
Objective: To investigate the prevalence and related factors of hyperuricemia among children and adolescents in Baotou, Inner Mongolia. Methods: The data of children and adolescents aged 3-18 years from January 2021 to June 2022 were collected. The eligible children and adolescents were taken as the research objects, and the data were sorted out and the results were statistically analyzed. Results: The difference of SUA level between different genders and age groups was statistically significant (P＜0.05); the detection rates of HUA in boys aged 3-6, 7-9 and 10-18 years old were 4.93%, 3.21% and 4.41%, respectively. The detection rates of HUA in girls in the above age groups were 4.44%, 3% and 2%, respectively. Among boys, there were significant differences in BUN, Cr, AST, Glu and blood lipid levels between HUA group and normal group (P＜0.05), and among girls, there were significant differences in AST levels between HUA group and normal group (P＜0.05). The results of correlation analysis showed that the SUA level in boys was positively correlated with BUN, Cr, ALT, TG and TC (P＜0.05), while that in girls was negatively correlated with Glu (P＜0.05), and positively correlated with BUN, Cr and ALT (P＜0.05). The results of multivariate logistic regression analysis showed that BUN and TC were the influencing factors of male HUA, and Glu was the influencing factor of female HUA. Conclusion: The serum uric acid level of children and adolescents in Baotou urban area is different in different ages and genders, and the detection rate of hyperuricemia in boys is higher than that in girls. Hyperuricemia can cause changes in BUN, Cr, AST, Glu and blood lipid levels; TC, BUN and Glu are the influencing factors of hyperuricemia in children and adolescents.
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