目的: 探讨分析磁共振成像(MRI)联合脑脊液乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、总蛋白(TP)诊断化脓性脑膜炎的应用效果。方法: 选取2019 年4月-2021年3月收治的40例化脓性脑膜炎(PM组)、40例病毒性脑膜炎(VE组)以及40例因其他疾病(非中枢神经系统感染)而行脑脊液检查的患者(非脑膜炎组)为研究对象,获取患者的脑脊液指标检查结果与MRI检查结果,并进行比较分析。结果: PM组患者的MRI阳性检出率与VE组比较无差异(P＞0.05);但PM组、VE组患者的MRI阳性检出率均大于非脑膜炎组(P＜0.05);PM组患者的LDH、AST、TP均高于VE组、非脑膜炎组(P＜0.05);PM组的LDH、AST阳性检出率均大于VE组、非脑膜炎组(P＜0.05)。LDH确诊率是37.50 %、AST确诊率是25.00 %、TP确诊率是7.50 %、 MRI确诊率是100 %、LDH+AST+TP+MRI确诊率是100 %。结论: 联合应用MRI、LDH、AST、TP诊断化脓性脑膜炎,检出阳性率高,检出准确性大,具有显著应用价值。
Objective: To investigate the application value of magnetic resonance imaging (MRI) combining with cerebrospinal fluid lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and total protein (TP) in the diagnosis of suppurative meningitis. Methods: Forty patients with purulent meningitis (PM group), 40 patients with viral meningitis (VE group) and 40 patients underwent cerebrospinal fluid examination due to other diseases (not central nervous system infection) (Non-meningitis group) in our hospital were selected as research objects from April 2019 to March 2021. The cerebrospinal fluid examination results and MRI examination results were obtained and compared. Results: There was no difference on the positive rate of MRI examination between the PM group and the VE group (P＞0.05). However, the positive rates of MRI in the PM group and VE group were higher than that in the Non-meningitis group (P＜0.05). LDH, AST and TP level in the PM group were higher than those in the VE group and Non-meningitis group (P＜ 0.05). The positive rates of LDH and AST in the PM group were higher than those in the VE group and Non-meningitis group (P＜0.05). The diagnostic rates of LDH, AST, TP, MRI and LDH + AST + TP + MRI were 37.50 %, 25.00 %, 7.50 %, 100 %, and 100 % respectively. Conclusion: The combination of MRI, LDH, AST and TP in the diagnosis of suppurative meningitis has high positive rate and high accuracy, which is of significant application value.
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