目的: 探讨急性冠脉综合征(acute coronary syndrome,ACS)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者冠状动脉病变程度与中性粒细胞与高密度脂蛋白比值(neutrophil to high-density lipoprotein ratio,NHR)、单核细胞与高密度脂蛋白比值(monocyte to high-density lipoprotein ratio,MHR)的相关性。方法: 选取2019年6月-2021年6月于包头市中心医院住院经冠状动脉造影确诊为ACS合并T2DM患者(151例),并按照冠脉病变程度将ACS合并T2DM组分为轻度组(Gensini评分≤40分)(69例)和重度组(Gensini评分＞40分)(82例)。结果: NHR、MHR在重度组中高于轻度组,差异有统计学意义,ACS合并T2DM组MNR、NHR与Gensini评分呈正相关。多因素Logistic 分析发现NHR升高是ACS合并T2DM冠脉病变严重程度的危险因素。绘制ROC曲线NHR预测ACS合并T2DM患者冠脉病变程度的最佳值为5.276,灵敏度是61.0 %,特异度是94.2 %,曲线下面积为0.726。结论: ACS合并T2DM患者冠脉病变程度与NHR、MHR呈正相关。
Objective: To investigate the relationship between the severity of coronary artery disease and the ratio of neutrophil to high density lipoprotein (NHR) and monocyte to high density lipoprotein (MHR) in patients with ACS complicated with T2DM. Methods: One hundled and fifty one patients who were diagnosed as ACS combining with T2DM by CAG in Baotou Central Hospital from June 2019 to June 2021 were selected as study objects. All selected patients were divided into mild group (Gensini score ≤40) (69 cases) and severe group (Gensini score > 40) (82 cases) based on the severity of coronary artery disease. Results: NHR and MHR in the severe group were higher than those in the mild group, and the difference was statistically significant. MNR and NHR were positively correlated with Gensini score in ACS patients combined with T2DM. Multivariate logistic analysis showed that increased NHR was a risk factor for the severity of ACS complicated with T2DM coronary artery disease. The best value of ROC curve for NHR to predict the severity of coronary artery disease in ACS patients with T2DM was 5.276, with a sensitivity of 61.0 %, and a specificity of 94.2 %. The AUC for NHR was 0.726. Conclusion: The severity of coronary artery disease in ACS patients combined with T2DM is positively correlated with NHR and MHR.
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