目的: 探讨炎症指标、凝血及生化指标在妊娠期高血压疾病中的水平及临床意义。方法: 选取2019年8月至2021年8月在包头医学院第一附属医院分娩孕妇223人为研究对象,其中包括对照组113例健康孕妇,病例组110例妊娠期高血压疾病患者。比较病例组与对照组单核细胞与淋巴细胞比值(monocyte to lymphocyte ratio,MLR),凝血酶原时间(prothrombin time,PT)、部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、纤维蛋白原(fibrinogen,FIB),血尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,Cr)、尿酸(uric acid,UA)指标的差异。结果: 病例组与对照组年龄与孕周比较,差异具有统计学意义(P<0.05 )。病例组与对照组比较临床指标的MLR、BUN、Cr、UA、TT、PT水平差异有统计学意义(P<0.05 ),APTT、FIB水平差异无统计学意义(P>0.05)。年龄、MLR、BUN、Cr、UA、TT与妊娠期高血压疾病的发病率成正相关,PT与妊娠期高血压疾病发病率呈负相关,差异具有统计学意义(P< 0.05)。APTT、FIB水平与妊娠期高血压疾病发病率无显著相关性(P>0.05)。结论: 妊娠期高血压疾病患者机体的炎症、凝血水平较正常妊娠高,同时生化指标异常。通过对炎症、凝血、生化指标进行检测,为临床诊治提供重要依据。
Objective: To investigate the levels and clinical significance of inflammatory indexes, coagulation and biochemical indexes in hypertensive disorders of pregnancy. Methods: A total of 223 pregnant women who gave birth in the First Affiliated Hospital of Baotou Medical College from August 2019 to August 2021 were selected as the research subjects, including 113 healthy pregnant women in the control group and 110 patients with gestational hypertension in the case group. The differences in monocyte to lymphocyte ratio (MLR), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), blood urea nitrogen (BUN), creatinine (Cr) and uric acid (UA) between the case group and the control group were compared. Results: There were significant differences in age and gestational age in the general clinical data between the case group and the control group (P<0.05). There were significant differences in the levels of MLR, BUN, Cr, UA, TT and PT between the case group and the control group (P<0.05); while there was no significant difference in APTT and FIB levels between the case group and the control group (P>0.05). Age, MLR, BUN, Cr, UA, TT were positively correlated with the occurrence of gestational hypertension, and PT was negatively correlated with the occurrence of gestational hypertension, and the differences were statistically significant (P<0.05); while APTT and FIB levels were not associated with the occurrence of gestational hypertension (P>0.05). Conclusion: The levels of inflammation and coagulation in patients with gestational hypertension are higher than those in normal pregnancy, and the renal function indexes are abnormal. Through the detection of inflammation, coagulation and renal function indexes, it provides an important basis for clinical diagnosis and treatment.
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