目的: 分析糖尿病肾病(diabetic nephropathy,DN)与血尿酸(serum uric acid,SUA)、白介素-8(interleukin,IL-8)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)之间的关系。方法: 选择2020年9月-2021年6月收治的2型糖尿病患者130例,依据患者尿白蛋白排泄率(UAER)或24 h尿蛋白定量将病例分为3组,单纯2型糖尿病组(UAER<20 μg/min或24 h尿蛋白定量<30 mg)49例,微量蛋白尿组(UAER 20~200 μg/min或24 h尿蛋白定量30~300 mg)37例,大量蛋白尿(UAER>200 μg/min或24 h尿蛋白定量>500 mg)44例,另收集同期44例健康体检者作为对照组。采用酶联免疫吸附法(ELISA)检测各组血IL-8、TNF-α水平并进行对比分析。结果: 与对照组相比,三组患者的血尿酸水平逐渐升高(P＜0.05),且血IL-8与TNF-α水平随着尿白蛋白量的增加而明显升高(P＜0.05);患者的血尿酸水平及炎性因子IL-8与TNF-α的表达具有正相关性(P＜0.05)。结论: 2型糖尿病患者的血尿酸水平与尿白蛋白水平升高呈相关性,且高尿酸血症相关的炎症因子IL-8、TNF-α与尿白蛋白升高也呈明显相关性,考虑2型糖尿病肾病由多种因素所致,其中炎症反应可能起着重要的作用。

Objective: to analyze the association between diabetic nephropathy and serum uric acid, interleukin-8 and tumor necrosis factorαRelationship between the three. Methods: the analysis subjects a total of 130 type 2 diabetic patients admitted to our hospital from September 2020 to June 2021 were selected, and the selected cases were divided according to the urinary albumin excretion rate(UAER) or (24h urinary protein quantification): 49 in type 2 diabetes alone group (UAER＜20 μg/min or 24 h urinary protein quantification＜30 mg ), 37 in microalbuminuria group (UAER 20-200 μg/min or 24 h urinary protein quantification 30-300mg ),And 44 cases with massive proteinuria (UAER＞200 μg/min or 24 h urinary protein quantification ＞500 mg ), another 44 healthy individuals in the same period were collected and classified as the control group.Interleukin-8 (IL-8) and TNF were measured by enzyme-linked immunosorbent assay (ELISA) in all patientsαLevels.Serum uric acid, interleukin-8, and TNF were measured in the four groups according to different grades of urinary albumin excretionαA comparative analysis was performed. Results: compared with healthy controls, patients with type 2 diabetes alone and those with microalbuminuria had increased serum uric acid levels, whereas those with macroalbuminuria had significantly higher serum uric acid levels (P＜0.05).Interleukin-8 and TNF in four cohorts-αLevels were significantly higher with increasing urinary albumin volume (P＜0.05).At the same time, the serum uric acid levels and the expression of inflammatory factors in the four groups of patients had a further proportional Association (P＜0.01). Conclusion: there was a significant correlation between serum uric acid level and urinary albumin level in patients with type 2 diabetes. And hyperuricemia related inflammatory factors IL-8 and TNF- α It is also related to the elevation of urinary albumin. Therefore, the occurrence of type 2 diabetic nephropathy is caused by a variety of factors. Inflammation and oxidative stress play an important role.