miRNA对肾足细胞损伤的影响*

doi:10.16833/j.cnki.jbmc.2022.12.017

包头医学院学报 ›› 2022, Vol. 38 ›› Issue (12): 86-90.doi: 10.16833/j.cnki.jbmc.2022.12.017

miRNA对肾足细胞损伤的影响^*

苑佳奇, 沈晓丹, 张志凤, 丁海麦, 张学明

包头医学院基础医学与法医学院,内蒙古包头 014040

收稿日期:2022-04-25 出版日期:2022-12-25 发布日期:2023-01-06
通讯作者: 张学明
基金资助:
*内蒙古自治区自然科学基金项目(2020MS08007);内蒙古自治区科技创新引导奖励资金项目(2019)

Effect of miRNA on renal podocyte injury

YUAN Jiaqi, SHEN Xiaodan, ZHANG Zhifeng, DING Haimai, ZHANG Xueming

School of Basic Medicine and Forensic Medicine,Baotou Medical College,Baotou 014040,China

Received:2022-04-25 Online:2022-12-25 Published:2023-01-06

摘要/Abstract

摘要： 微RNA(microRNAs;miRNA,又译小分子RNA)是真核生物中广泛存在的一种长21-23个核苷酸的RNA分子,可调节其他基因的表达。其通过与目标mRNA进行特异结合,作为许多细胞过程的关键参与者,抑制转录后基因表达,在调控基因表达、细胞周期、生物体发育等方面起着重要作用。最近的研究表明,microRNA在肾脏正常生理功能和疾病中有重要作用,可能成为肾脏疾病中的预后标记物和(或)潜在治疗目标。

关键词: microRNA, 肾足细胞, 肾脏疾病

Abstract: Objective: microRNAs (miRNA,also translated into small RNAs) is a kind of RNA molecule with 21-23 nucleotides in length widely existing in eukaryotes,which can regulate the expression of other genes. As a key participant in many cellular processes,it inhibits post-transcriptional gene expression by specifically binding to the target mRNA,and plays an important role in regulating gene expression,cell cycle,and biological development. Recent studies have shown that microRNAs play an important role in normal renal physiological functions and diseases,and may become prognostic markers and / or potential therapeutic targets in renal diseases.

Key words: microRNA, Renal podocytes, Kidney diseases

苑佳奇, 沈晓丹, 张志凤, 丁海麦, 张学明. miRNA对肾足细胞损伤的影响^*[J]. 包头医学院学报, 2022, 38(12): 86-90.

YUAN Jiaqi, SHEN Xiaodan, ZHANG Zhifeng, DING Haimai, ZHANG Xueming. Effect of miRNA on renal podocyte injury[J]. Journal of Baotou Medical College, 2022, 38(12): 86-90.

参考文献

[1] Correia De Sousa M,Gjorgjieva M,Dolicka D,et al.Deciphering miRNAs’ action through miRNA editing[J].Int J Mol Sci,2019,20(24):6249.
[2] Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
[3] Lagos-Quintana M,Rauhut R,Lendeckel W,et al.Identification of novel genes coding for small expressed RNAs[J].Science,2001,294(5543):853-858.
[4] Wei Q,Mi Q,Dong Z.The regulation and function of micrornas in kidney diseases[J].IUBMB Life,2013,65(7):602-614.
[5] Garg P.A Review of podocyte biology[J].Am J Nephrol,2018,47(Suppl.1):3-13.
[6] Nagata M.Podocyte injury and its consequences[J].Kidney Int,2016,89(6):1221-1230.
[7] Assady S,Wanner N,Skorecki KL,et al.New insights into podocyte biology in glomerular health and disease[J].J Am Soc Nephrol,2017,28(6):1707-1715.
[8] Zhao SM,Zhang T,Qiu Q,et al.MiRNA-337 leads to podocyte injury in mice with diabetic nephropathy[J].Eur Rev Med Pharmacol Sci,2019,23(19):8485-8492.
[9] Harvey SJ,Jarad G,Cunningham J,et al.Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease[J].J Am Soc Nephrol, 2008,19(11):2150-2158.
[10] Zhdanova O,Srivastava S,Di L,et al.The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy[J].Kidney international,2011,80(7):719-730.
[11] Hill N,Michell DL,Ramirez-Solano M,et al.Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA[J].PLoS One,2020,15(3):e224852.
[12] Gebeshuber CA,Kornauth C,Dong L,et al.Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1[J].Nature Med,2013,19(4):481-487.
[13] Herman-Edelstein M,Scherzer P,Tobar A,et al.Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy[J].J Lipid Res,2014,55(3):561-572.
[14] Christofides A,Papagregoriou G,Dweep H,et al.Evidence for miR-548c-5p regulation of FOXC2 transcription through a distal genomic target site in human podocytes[J].Cell Mol Life Sci,2020,77(12):2441-2459.
[15] Su H,Qiao J,Hu J,et al.Podocyte-derived extracellular vesicles mediate renal proximal tubule cells dedifferentiation via microRNA-221 in diabetic nephropathy[J].Mol Cell Endocrinol,2020,518:111034.
[16] Rahbar Saadat Y,Hejazian SM,Nariman-Saleh-Fam Z,et al.Glucocorticoid receptors and their upstream epigenetic regulators in adults with steroid-resistant nephrotic syndrome[J].Biofactors,2020,46(6):995-1005.
[17] Duan Y,Luo Q,Wang Y,et al.Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy[J].J Bioll Chem,2020,295(37):12868-12884.
[18] Wang L,Li H.MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3[J].Biosci Rep,2020,40(4):BSR20193653.
[19] Yao T,Zha D,Hu C,et al.Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy[J].Gene,2020,747:144661.
[20] Li X,Yu HM.Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miRNA-302b-3p to upregulate TIMP3[J].Eur Rev Med Pharmacol Sci,2020,24(9):4963-4970.
[21] Roy D,Modi A,Khokar M,et al.Microrna 21 emerging role in diabetic complications: A Critical Update[J].Curr Diabetes Rev,2021,17(2):122-135
[22] Li M,Guo Q,Cai H,et al.miR-218 regulates diabetic nephropathy via targeting IKK-β and modulating NK-κB-mediated inflammation[J].J Cell Physiol,2020,235(4):3362-3371.
[23] Dai Y,Gao M,Li L,et al.MicroRNA-874-3p aggravates doxorubicin-induced renal podocyte injury via targeting methionine sulfoxide reductase B3[J].Oxid Med Cell Longev,2020,2020: 9481841.
[24] Liao Y,Wang Z,Wang L,et al.MicroRNA-27a-3p directly targets FosB to regulate cell proliferation,apoptosis,and inflammation responses in immunoglobulin a nephropathy[J].Biochem Biophys Res Commun,2020,529(4):1124-1130.

miRNA对肾足细胞损伤的影响^*

Effect of miRNA on renal podocyte injury

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