Objective: To investigate the expression levels of plasma miRNA-208a-3p, miRNA-499a-5p and miRNA-221-3p and their correlation with cardiac troponin (cTnⅠ) and heart fatty acid-binding protein (H-FABP) in patients acute myocardial infarction (AMI), and to explore their potential value for early diagnosis of AMI. Methods: A total of 52 patients with AMI were continuously collected as AMI group, and 24 patients with non-cardiac chest pain were collected as control group.High-throughput sequencing was used to detect the expression levels of three miRNAs in plasma of the two groups.Pearson analysis was used to analyze the correlation between the expression levels of three miRNAs and cTnⅠ and H-FABP.The receiver operating characteristic curve (ROC) was used to analyze the area under the curve (AUC) of the three miRNAs in the diagnosis of AMI alone and in combination. Results: Compared with the control group, the expression levels of these three miRNAs in the plasma of AMI group were significantly increased (P＜0.05), which were positively correlated with cTnⅠ and H-FABP respectively (P＜0.05), and the AUC of single diagnosis of AMI was 0.794, 0.772 and 0.806, respectively; the AUC of combined diagnosis of AMI was 0.862. Conclusion: Plasma miRNA-208a-3p, miRNA-499a-5p and miRNA-221-3p can be used as potential biomarkers for early diagnosis of AMI, and the potential diagnostic value of combined indicators is higher.
YU Ye
,
ZHAO Ruiping
,
LI Ping
. The correlation between plasma microRNA and cTnⅠ, H-FABP in patients with acute myocardial infarction and its potential diagnostic value[J]. Journal of Baotou Medical College, 2022
, 38(9)
: 26
-30
.
DOI: 10.16833/j.cnki.jbmc.2022.09.006
[1] Mir R,Elfaki I,Khullar N,et al.Role of selected miRNAs as diagnostic and prognostic biomarkers in cardiovascular diseases,including coronary artery disease,myocardial infarction and atherosclerosis[J].J Cardiovasc Dev Dis,2021,8(2):22.
[2] Thakur P,Saini RV,Chhillar AK,et al.Alteration in the expression of microRNA-21 regulated target genes:role in breast cancer[J].BIOCELL,2022,46(2):309-324.
[3] Zhai CN,Li R,Hou K,et al.Value of blood-based microRNAs in the diagnosis of acute myocardial infarction:a systematic review and meta-analysis[J].Front Physiol,2020,11:691.
[4] Cao RY,Zheng HC,Guo JJ,et al.Prognostic value of plasma biomarkers in patients with acute coronary syndrome:a review of advances in the past decade[J].Biomark Med,2016,10(5):525-535.
[5] Navickas R,Gal D,Lauceviius A,et al.Identifying circulating microRNAs as biomarkers of cardiovascular disease:a systematic review[J].Cardiovasc Res,2016,111(4):322-337.
[6] Benjamin EJ,Muntner P,Alonso A,et al.Heart disease and stroke statistics-2019 update:a report from the American heart association[J].Circulation,2019,139(10):e56-e528.
[7] Reed GW,Rossi JE,Cannon CP.Acute myocardial infarction[J].Lancet,2017,389(10065):197-210.
[8] Thygesen K,Alpert JS,Jaffe AS,et al.Fourth universal definition of myocardial infarction (2018)[J].Circulation,2018,138(20):e618-e651.
[9] Ye XD,He Y,Wang S,et al.Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis [J].Acta Pharmacol Sin,2018,39(7):1155-1163.
[10] Myhre PL,O'Meara E,Claggett BL,et al.Cardiac troponin I and risk of cardiac events in patients with heart failure and preserved ejection fraction[J].Circ Heart Fail,2018,11(11):e005312.
[11] Vallabhajosyula S,Sakhuja A,Geske JB,et al.Role of admission troponin-T and serial troponin-T testing in predicting outcomes in severe sepsis and septic shock[J].J Am Heart Assoc,2017,6(9):e005930.
[12] Liu B,Yang H,Taher L,et al.Identification of prognostic biomarkers by combined mRNA and miRNA expression microarray analysis in pancreatic cancer[J].Transl Oncol,2018,11(3):700-714.
[13] Xin YY,Yang CJ,Han ZJ.Circulating miR-499 as a potential biomarker for acute myocardial infarction[J].Ann Transl Med,2016,4(7):135.
[14] Coskunpinar E,Cakmak HA,Kalkan AK,et al.Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction[J].Gene,2016,591(1):90-96.
